Results of individual studies
| Studies | Patients (n (%)) | Baseline characteristics | SICH (n (%)) | Favourable outcome (n (%)) | Mortality at 3 months (n (%)) |
| Toni15 | |||||
| ≤80 years | 207 | More females, diabetics, AF, patients on antiplatelets in >80 year group | 10 (4.8) | (mRS 0–2) 121 (58.5) | 22 (10.6) |
| >80 years | 41 (16.5) | 2 (4.8) | 18 (44) | 14 (34.1) | |
| p Value | p=1.0 | NS | p<0.001 | ||
| Uyttenboogaart17 | |||||
| <80 years | 111 | Older patients had longer time to treatment and had fewer lacunar strokes | 4 (3.6) | 40 (36.0) | 14 (12.6) |
| ≥80 years | 31 (22) | 3 (9.7) | 5 (16.1) | 14 (45.2) | |
| p Value | p=0.176 | p=0.004 | p<0.001 | ||
| Gómez-Choco18 | |||||
| ≤80 years | 108 | Older patients were more often on antiplatelets and had longer ‘time to rtPA’ | 6 (5.5) | (included mRS 2) 39 (37) | 11 (10) |
| >80 years | 49 (31.2) | 3 (6) | 12 (25) | 3 (6) | |
| p Value | p≥0.05 | p≥0.05 | p≥0.05 | ||
| Meseguer19 | |||||
| <80 years | 107 | More females, less smokers, higher baseline NIHSS and cardioembolic source in elderly | 8 (7.5) | 40 (37.4) | 12 (11.2) |
| ≥80 years | 22 (17) | 3 (13.6) | 6 (27.3) | 6 (27.3) | |
| p Value | p=0.40 | p=0.37 | p value NA | ||
| Ringleb13 | |||||
| <80 years | 378 | More females and higher SGL in elderly group. Longer time to treatment in MRI selection | 20 (5.3) | 158 (41.8) | 48 (12.7) |
| ≥80 years | 90 (19) | 6 (6.7) | 17 (18.9) | 26 (28.9) | |
| p Value | p>0.05 | p Value NA | p<0.001 | ||
| Mouradian11 | |||||
| <80 years | 65 | Higher incidence of CHF and HTN in elderly. More elderly patients had higher baseline NIHSS | 4 (6.2) | (mRS 0–2) 38 (58.5) | CVA related deaths 7 (10.8) |
| ≥80 years | 31 | 3 (9.7) | 5 (16.1) | 10 (32.3) | |
| p Value | p=0.69 | p<0.001 | p=0.01 | ||
| Berrouschot14 | |||||
| <80 years | 190 | Only baseline NIHSS compared p=0.115 | 5 (2.6) | 89 (46.8) | 10(5.3) |
| ≥80 years | 38 (16) | 1 (2.6) | 10 (26.3) | 8 (21.1) | |
| p Value | p=1.0 | p=0.021 | p=0.004 | ||
| Engelter16 | |||||
| <80 years | 287 | More females, higher SBP, cardioembolic source and AF in elderly group | 24 (8) | 107 (37) | 35 (12) |
| ≥80 years | 38 (12) | 5 (13) | 11 (29) | 12 (32) | |
| p Value | p=0.36 | p=0.37 | p=0.005 | ||
| Sylaja12 | |||||
| <80 years | 865 | More females, higher incidence of HTN, AF, IHD, CHF, higher pretreatment SBP and baseline NIHSS in ≥80 group and less smoker and cholesterol | 40 (4.6) | 40.2 | 18.2 |
| ≥80 years | 270 (23.8) | 12 (4.4) | 25.9 | 35.3 | |
| p Value | p=1.0 | p=0.001 | p=0.001 | ||
| Oostenbrugge20 | |||||
| <80 years | 139 | More females, higher incidence of IHD and CHF in ≥80 year group and were less often smokers | 4 (2.9) | 62 (45) | Not available |
| ≥80 years | 45 (24) | 5 (11.1) | 12 (27) | ||
| OR (95% CI) | OR 4.2 (95% CI 1.08 to 16.46) | OR 2.2 (95% CI 1.06 to 4.46) | |||
| Parnetti21 | |||||
| <80 years | 49 | Higher incidence of previous stroke and antiplatelet therapy in ≥80 year group | 1 (2) | 20 (40.8) | 4 (8.2) |
| ≥80 years | 23 (30.5) | 1 (4.3) | 10 (43.4) | 3 (13.0) | |
| p Value | p>0.05 | p>0.05 | p>0.05 | ||
| Tanne10 | |||||
| <80 years | 159 | Higher incidence of diabetes and current smokers in <80 year and higher pretreatment systolic BP in elderly | 10 (6) | Not calculated at 3 months | Not calculated at 3 months |
| ≥80 years | 30 (15.8) | 1 (3) | |||
| p Value | p=0.99 | ||||
| Chen9 | |||||
| <80 years | 127 | More females and cardioembolic strokes in elderly group | 8 (6.3) | Not calculated at 3 months | Not calculated at 3 months |
| ≥80 years | 56 (44.1) | 4 (7.1) | |||
| p Value | p=0.90 | ||||
AF, atrial fibrillation; BP, blood pressure; CHF, congestive heart failure; CVA, cardiovascular accident; HTN, hypertension; IHD, ischaemic heart disease; mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale; NINDS, National Institute of Neurological Diseases and Stroke; rtPA, reverse transcriptase plasminogen activator; SBP, systolic blood pressure; SGL, serum glucose level; SICH, symptomatic intracranial haemorrhage.