Electrophysiological findings in patients with SCA6
| Normal values | Family - patient | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| D-1 | E-1 | F-1 | E-2 | H-1 | A-2 | K-2 | L-2 | M-1 | N-1 | ||
| Peroneal nerve DL (ms) | < 4.7 | 4.1 | 5.2 | 4.3 | 3.7 | 4.0 | 5.0 | 6.2 | 3.8 | 3.5 | 3.4 |
| CMAP (mV) | > 5.0 | 7.6 | 4.0 | 6.0 | 7.1 | 6.1 | 1.5 | 2.9 | 6.4 | 4.7 | 5.8 |
| MNCV (m/s) | > 42.0 | 52.7 | 44.2 | 45.9 | 49.0 | 49.8 | 45.8 | 38.8 | 52.6 | 47.8 | 44.8 |
| F wave (ms) | < 56.0 | 40.3 | 60.0 | 50.3 | 44.2 | 47.8 | 53.9 | 56.6 | 43.1 | 48.9 | 53.9 |
| Tibial nerve DL (ms) | < 5.2 | 3.8 | 5.7 | 3.3 | 3.0 | 3.8 | 5.5 | 4.0 | 3.7 | 3.9 | 4.2 |
| CMAP (mV) | > 10.0 | 13.0 | 10.0 | 21.7 | 13.0 | 15.9 | 12.3 | 7.5 | 23.1 | 10.8 | 15.1 |
| MNCV (m/s) | > 42.0 | 48.5 | 39.6 | 48.2 | 42.7 | 49.3 | 49.4 | 40.2 | 49.1 | 50.2 | 48.7 |
| F wave (ms) | < 56.0 | 44.0 | 61.0 | 49.4 | 46.2 | 49.4 | 57.3 | 57.6 | 44.9 | 53.1 | 57.4 |
| Sural nerve SNAP (μV) | > 10.0 | 12.0 | 17.0 | 21.0 | 21.0 | 7.5 | 6.7 | 4.3 | 23.0 | 6.3 | 8.2 |
| SNCV (m/s) | > 47.0 | 56.0 | 38.0 | 47.3 | 55.1 | 51.8 | 44.0 | 50.0 | 59.6 | 46.4 | 53.4 |
| EMG (TA) PSA | 0 | 0 | 0 | 0 | 0 | + | 0 | 0 | 0 | 0 | 0 |
| Neurogenic | 0 | 0 | + | 0 | 0 | + | + | + | 0 | + | 0 |
| MEP PMCT (FDI) (ms) | < 16.5 | 15.2 | 15.2 | 14.1 | 15.2 | 16.8 | |||||
| CMCT (FDI) (ms) | < 8.5 | 6.3 | 7.4 | 8.2 | 8.2 | 5.5 | |||||
| PMCT (TA) (ms) | < 16.2 | 14.1 | 14.1 | 14.8 | 14.1 | 17.1 | |||||
| CMCT (TA) (ms) | < 18.5 | 18.0 | 15.6 | 13.3 | 20.0 | 14.8 | |||||
Symbols for patients as in table 1. DL=distal latency; MNCV=motor nerve conduction velocity; CMAP=compound muscle action potential; SNAP=sensory nerve action potential; SNCV=sensory nerve action potential; 0=normal; +=mild neurogenic changes; Abnormal values in italics. MEP=Motor evoked potentials; FDI=first dorsal interosseus muscle; TA=tibialis anterior muscle; PMCT=peripheral motor conduction time; CMCT=central motor conduction time.