Table 2

Paraneoplastic encephalomyelitis and sensory neuronopathy associated with HuAb (the anti-Hu syndrome)

Symptom	Presenting symptoms^2-150(%)	Site of pathology
Sensory deficits (usually asymmetric) with or without pain^2-151	69	Dorsal root and trigeminal ganglia
Motor incoordination, tremor, ataxia	23	Cerebellum
Limbic encephalopathy: memory loss, depression, seizures	16	Hippocampus, insular cortex
Motor weakness, fasciculations, hyporeflexia, or hyperreflexia	14	Spinal cord
Dysphagia, dysarthria, ocular paresis, opsoclonus	11	Brainstem
Orthostatic hypotension, intestinal pseudo-obstruction, sexual impotence, urinary retention, abnormal pupillary reflex	10	Autonomic nervous system

↵2-150 In 173 patients with anti-Hu syndrome and pathologically confirmed small cell lung cancer, 31% had more than one presenting symptom.
↵2-151 Sensory deficits and pain are the most frequent symptoms, either in isolation or associated with any of the other symptoms.