Pharmacokinetic characterisitics of sumatriptan, naratriptan, and zolmitriptan
| Sumatriptan | Naratriptan | Zolmitriptan | |
|---|---|---|---|
| T1/2 | 2 | 6 | 3 |
| TMAX(h) | 2 | 2–3 | 1 |
| Oral bioavailability (%) | 14 | 63–74 | 40 |
| Metabolism and excretion (main routes) | MAO | Renal/P-450 | P-450/MAO |
| LogDpH7.4 2-150 53 | −1.3 | −0.02 | −1.0 |
↵2-150 Measure of lipophilicity.
Assembled from published data.20,29-31,40-42,44
MAO=monoamine oxidase.