Correlation of regional multiple sclerosis lesion volumes with Kurtzke functional systems score and EDSS (Spearman’s rank correlation)
| Regional lesion volume | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Posterior fossa | Subcortical | Periventricular | Discrete | ||||||||||
| CSE | fFLAIR | CSE | fFLAIR | CSE | fFLAIR | CSE | fFLAIR | ||||||
| Disability: | |||||||||||||
| Cerebellar | +++ | +++ | ++ | + | ++ | ++ | ++ | +++ | |||||
| Brain stem | ++ | ++ | + | + | ++ | ++ | ++ | ++ | |||||
| Pyramidal | ++ | + | + | + | +++ | ++ | ++ | + | |||||
| Sphincter | ++ | − | − | − | + | + | + | + | |||||
| Visual | − | − | − | − | + | + | − | − | |||||
| Mental | + | − | − | − | − | − | − | − | |||||
| Sensory | − | − | − | − | − | − | − | − | |||||
| Overall EDSS | ++ | ++ | + | + | +++ | ++ | + | + | |||||
− No significant correlation (p>0.05); + r < 0.4, p<0.05; ++ r ⩾ 0.4, p<0.01; +++ r⩾ 0.5, p<0.001.