Table 1

Regional brain uptake ratios of FDG in asymptomatic gene carriers of Machado–Joseph disease (MJD)

		Asymptomatic MJD gene carriers		Control subjects (mean (SD)) (n=10)
		Subject 1	Subject 2	Control subjects (mean (SD)) (n=10)		Subject 3	Subject 4	Subject 5	Subject 6	Subject 7
Age (y)	13	22	23	25	25	39	47	46.9 (11.8)
CAG repeat number	80	63	76	73	73	62	69	21.7 (7.0)
CH/TH	0.72 (82)	0.77 (88)	0.82 (93)	0.79 (90)	0.78 (89)	0.81 (92)	0.84 (95)	0.88 (0.03)
BS/TH	0.73 (94)	0.59 (76)	0.76 (97)	0.60 (77)	0.65 (83)	0.68 (81)	0.77 (99)	0.78 (0.08)
O/TH	0.84 (91)	0.78 (85)	0.86 (93)	0.87 (95)	0.78 (85)	0.97 (105)	0.95 (103)	0.92 (0.04)
P/TH	1.0 (104)	0.97 (101)	1.20 (125)	1.04 (108)	1.08 (113)	1.20 (125)	1.05 (109)	0.96 (0.03)
T/TH	0.95 (106)	0.92 (102)	1.11 (123)	1.09 (121)	1.00 (111)	1.04 (116)	1.02 (113)	0.90 (0.04)

Numbers in parentheses for the asymptomatic MJD gene carriers represent percentage of each ratio compared with the mean of control subjects.
CH = cerebellar hemisphere; BS = brainstem; O = occipital; P = parietal; T = temporal; TH = thalamus.