Comparison of regional brain uptake ratios of FDG in asymptomatic Machado–Joseph disease (MJD) gene carriers, patients with Machado–Joseph disease, and normal controls
| Patients with MJD (n=8)11 | Asymptomatic gene carriers (n=7) | Control subjects mean (SD) (n=10) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| FDG uptake ratios | Difference (95% CI)2-151 | Difference (95% CI)2-152 | FDG uptake ratios | Difference (95% CI)2-153 | |||||
| Age (y, mean (SD)) | 28.9 (10.3) | 27.7 (11.4) | 46.9 (11.8) | ||||||
| CAG repeat number (mean (SD)) | 73.4 (6.0) | 70.9 (6.7) | 21.7 (7.0) | ||||||
| CH/TH | 0.73 (SD 0.05) | −0.15 (−0.19 to −0.11)*** | −0.06 (−0.11 to −0.01)2-150 | 0.79 (SD 0.04) | −0.09 (−0.12 to −0.05)*** | 0.88 (0.03) | |||
| BS/TH | 0.63 (SD 0.07) | −0.15 (−0.23 to −0.07)** | −0.05 (−0.12 to 0.02) | 0.68 (SD 0.07) | −0.10 (−0.18 to 0.02)2-150 | 0.78 (0.08) | |||
| O/TH | 0.73 (SD 0.11) | −0.19 (−0.27 to −0.11)*** | −0.13 (−0.23 to −0.03)2-150 | 0.86 (SD 0.07) | −0.06 (−0.12 to 0.00)2-150 | 0.92 (0.04) | |||
| P/TH | 0.91 (SD 0.01) | −0.05 (−0.07 to −0.03) | −0.16 (−0.24 to −0.07)** | 1.07 (SD 0.09) | 0.11 (0.05 to 0.17)** | 0.96 (0.03) | |||
| T/TH | 0.87 (SD 0.09) | −0.03 (−0.10 to 0.04) | −0.15 (−0.23 to −0.06)** | 1.02 (SD 0.07) | 0.12 (0.06 to 0.18)*** | 0.90 (0.04) | |||
↵2-150 p<0.05; ** p<0.01;*** p<0.01.
↵2-151 Difference between regional FDG uptake ratios of subjects affected with MJD and that of control subjects.
↵2-152 Difference between regional FDG uptake ratios of subjects affected with MJD and that of asymptomatic gene carriers.
↵2-153 Difference between regional FDG uptake ratios of asymptomatic gene carriers and those of control subjects.
CH = cerebellar hemisphere; BS = brainstem; O = occipital; P = parietal; T = temporal; TH = thalamus.