Age of onset in Alzheimer’s disease according to the apoE genotype

First author		Reference		n		Age	Age of onset
First author		Reference		n		Age	1 or 2 ε4	No ε4	Comparison^1-150
Poirier	Lancet1993;342:697	91	75.1 (10.3)	73.6^1-151	77.6	Younger
Corder	Neurology1995;45:1323	97^1-152	79.4^1-151	71.1^1-151	71.4 (7.4)	NS
Frisoni	Ann Neurol1995;37:596	62	79.8^1-151	74.3^1-151	76.9 (4.6)	Younger
Lehtovirta	Neuroscience1995;67:65	26	68.9^1-151	67.2^1-151	66.2 (9.0)	NS
Gomez-Isla	Ann Neurol1996;39:62	329	77.8 (9.6)	70.8^1-151	73.8^1-151	Younger
Kukull	J Clin Epidemiol 1996;49:1143	234	80.2 (6.8)	76.1^1-151	77.5	Younger
Holmes	J Neurol Neurosurg Psychiatry 1996;61:580	164	81.9 (6.6)	75.5 (5.9)	78.7 (7.9)	Younger
Mak	Neurology1996;46:146	65	76.5 (8.3)	71.7^1-151	73.7 (8.5)	NS
Dal Forno	Arch Neurol1996;53:345	101	69.6^1-151	66.8^1-151	62.4 (8.8)	Older
Simões do Couto	This study	68	68.8 (7.9)	65.7 (7.1)	61.6 (7.6)	Older

↵1-150 Patients with ε4 allele younger or older than patients without ε4 allele, or non-significant difference (ns).
↵1-151 Calculated from the results in the cited paper.
↵1-152 Only sporadic cases considered.