Table 1

Clinical characteristics in patients with Alzheimer’s disease (AD) with (ε4+) and without (ε4−) ApoE ε4 allele and in healthy controls

ControlsAD ε4−AD ε4+
Number311116
Age (y)72.2 (3.9)69.1 (7.1)70.4 (9.9)
F/M20/116/56/10
Education (y)9.6 (3.7)5.8 (0.8)6.9 (2.2)
MMSE28.3 (1.5)22.3 (3.6)19.6 (3.7)
CDR 1/ CDR 26/58/8
Story recall, immediate9 (6)1-150 4 (3)
Story recall, delayed8 (7)** 2 (3)
List learning, immediate45 (6)22 (8)*** 12 (6)
List learning , delayed10 (0)7 (3)5 (3)
Heaton visual, immediate13 (3)6 (2)** 4 (2)
Heaton visual, delayed11 (3)2 (3)0 (1)
  • 1-150 p=0.05; **p<0.01; ***p<0.001, AD ε4− casesv AD ε4+ cases.

  • Values are means (SD). The stage of the Alzheimer’s disease was determined by the mini-mental status examination (MMSE) and clinical dementia rating scale (CDR). Student’s ttest.