Toxological data from patients poisoned with organophosphates
| Case No (compound) | Time after poisoning | Red blood cell AChE (mU/l) (normal 4.9-11.7) | Plasma BuChE (mU/l) (normal 2.4-8.3) | Lymphocyte-NTE (mU/g protein) (normal 6.5-16.5) | Blood concentration (μmol/l) |
|---|---|---|---|---|---|
| 1 (Methidathion) | 12 h | < 0.5 | < 0.5 | 5.61-150 | |
| 3 days | 10.7† | ||||
| 2 (Azinphos-methyl) | 12 h | 0 | 0 | ND | |
| 2 days | 8.2† | ||||
| 3 (Coumaphos) | 10 h | 0 | 0 | 8.6† | ND |
| 4 (Coumaphos) | 3 h‡ | < 0.5 | 0 | ND | 0.06 |
| 5 (Coumaphos) | 2 h | 0.08 | |||
| 20 h | 2.0 | < 0.5 | 12.5 | ||
| 6 (Chlorpyrifos) | 15 h | < 0.5 | ND | ||
| 40 days | 5.9 | 1.6 | 9.5 | ||
| 7 (Isofenphos) | 10 h | 0 | 0 | 5.9§ | ND |
| 8 (Trichlorfon) | 4 h | ND | 0 | ND | |
| 24 h | 9.2† | ||||
| 9 (Chlorpyrifos) | 3 days | < 0.5 | 0.7¶ | ||
| 30 days | 3.6 | < 0.5 | 5.9** | ||
| 10 (Methamidophos) | 8 h | < 0.5 | < 0.5 | 27.01-150 | |
| 21 h | 1.0†† | ||||
| 11 (Isofenphos + phoxim) | 3 h | < 0.5 | < 0.5 | ND | 10.1‡‡ |
| 0.3§§ |
↵1-150 Half life of about 10 hours. † Within normal range also at later measurements. ‡ Refers to the last episode. § Within normal values on day 3 (10.0 mU/g protein). ¶ Half life of about 2 days, but the chemical was detected up to 10 days after poisoning. ** Within normal values on day 45 (8.2 mU/g protein). †† Within normal values on day 9 (12.5 mU/g protein). ‡‡ Isofenphos. §§ Phoxim. ND = not done. AChE = acetyl cholinesterase; BuChE = butyryl cholinesterase; NTE = neuropathy target esterase.