Demographic and immunological characteristics of the diagnostic groups. Laboratory markers are shown at diagnosis of AIDS and at onset of brain disease
| No brain impairment | HIV dementia | Opportunistic brain disease | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n=914 | n=88 | n=107 | p Value | |||||||
| Sex (female (n (%)) | 32 (3.5) | 4 (4.5) | 5 (4.7) | 0.755 | ||||||
| IV drug user (n (%)) | 53 (5.8) | 5 (5.7) | 4 (3.7) | 0.680 | ||||||
| Heterosexual (n (%)) | 61 (6.7) | 6 (6.8) | 10 (9.3) | 0.528 | ||||||
| Age, mean in years (mean (95% CI)) | 36.5 (35.9–37.0) | 39.6 (37.7–41.5) | 37.1 (35.5–38.7) | 0.004 | ||||||
| CD4 count /10-9 l (mean (95% CI)): | ||||||||||
| AIDS (n=951) | 121 (111–132) | 84 (64–104) | 69 (52–86) | 0.001 | ||||||
| Onset brain disease (n=144) | — | 67 (37–96) | 60 (42–77) | 0.786 | ||||||
| CD8 count /10-9l (mean (95% CI)): | ||||||||||
| AIDS (n=844) | 858 (817–899) | 858 (712–1003) | 707 (606–809) | 0.072 | ||||||
| Onset brain disease (n=129) | — | 629 (475–782) | 611 (506–717) | 0.859 | ||||||
| Haemoglobin, mg/dl (mean (95% CI)): | ||||||||||
| AIDS (n=791) | 12.2 (12.1–12.4) | 11.9 (11.5–12.3) | 12.0 (11.5–12.4) | 0.161 | ||||||
| Onset brain disease (n=126) | — | 11.1 (10.6–11.5) | 11.8 (11.4–12.2) | 0.045 | ||||||
| Weight, kg (mean (95% CI)): | ||||||||||
| AIDS (n=389) | 68.5 (67.4–69.5) | 68.1 (64.8–71.4) | 68.9 (65.1–72.6) | 0.951 | ||||||
| Onset brain disease (n=48) | — | 69.5 (63.2–75.8) | 67.1 (63.9–70.4) | 0.239 | ||||||