Lesion volume measurements on baseline scans and for changes in lesion volume with the two techniques
| Technique | Mean | Median | Min | Max | ||
|---|---|---|---|---|---|---|
| Baseline lesion volume (cm3) | Manual outlining | 18.8 | 12.2 | 2.0 | 77.1 | |
| Contour method | 18.2 | 12.1 | 2.1 | 74.7 | ||
| Change in lesion volume (cm3) | Manual outlining | +2.5 | +0.8 | −3.4 | +14.9 | |
| Contour method | +1.8 | +0.5 | −4.4 | +14.8 | ||
The values were obtained by combining the results of the three raters for the 16 patients. However, the minimum and maximum values reflect the results of all observations regardless of rater. The intraclass correlation coefficient for agreement between the lesion volumes obtained with the two techniques was 0.996 for measurements on the baseline scans (bias 3%), and 0.910 for measurements of the change in lesion volume.