Bone mineral density and various serum biochemical tests in the vitamin D and placebo groups at baseline and after 18 months
| BMD and serum index (reference range)2-151 | Baseline | Per cent change after 18 months follow up (values at 18 months) | p Value2-150 |
|---|---|---|---|
| Bone mineral density (mm Al) (2.46 to 3.32): | |||
| Vitamin D | 2.054 (0.388) | −1.2 (3.7) (2.024 (0.375)) | |
| Placebo | 2.007 (0.650) | −6.7 (2.6) (1.859 (0.705)) | < 0.0001 |
| 25-OHD (ng/ml) (18.5 to 24.7): | |||
| Vitamin D | 11.0 (5.9) | 7.9 (31.5) (11.3 (4.3)) | |
| Placebo | 11.8 (6.9) | −3.1 (22.5) (11.6 (6.4)) | 0.37 |
| 1, 25-[OH]2D (pg/ml) (40.4 to 58.8): | |||
| Vitamin D | 27.6 (6.2) | 73.4 (57.8) (47.1 (16.1)) | |
| Placebo | 28.4 (9.4) | −2.4 (6.4) (26.9 (7.8)) | < 0.0001 |
| Ionised calcium (mmol/l) (1.242 to 1.307) | |||
| Vitamin D | 1.279 (0.041) | −1.7 (4.3) (1.255 (0.047)) | |
| Placebo | 1.270 (0.034) | 1.4 (4.9) (1.287 (0.039)) | 0.0018 |
| Intact PTH (pg/ml) (32 to 41) | |||
| Vitamin D | 35.1 (21.6) | −35.3 (39) (17.9 (5.3)) | |
| Placebo | 36.3 (20.5) | −3.9 (6.5) (34.0 (18.8)) | < 0.0001 |
| Intact BGP (ng/ml) (2.5 to 11.5) | |||
| Vitamin D | 7.91 (3.47) | −39 (58) (4.50 (2.44)) | |
| Placebo | 7.81 (3.06) | 11 (23) (8.41 (3.25)) | < 0.0001 |
| ICTP (ng/ml) (6.0 to 8.2) | |||
| Vitamin D | 4.59 (2.43) | −12.2 (7.2) (3.65 (1.06)) | |
| Placebo | 4.64 (1.69) | −2.9 (3.1) (4.54 (1.75)) | < 0.0001 |
Values are mean (SD). BMD=bone mineral density; 25-OHD=5-hydroxyvitamin D; 1, 25-[OH]2D=1, 25-dihydroxyvitamin D; PTH=prarthyroid hormone; BGP=bone Gla protein; ICTP=pyridinoline cross linked carboxyterminal telpeptide of type I collagen.
↵2-150 p Value from Wilcoxon rank sum test.
↵2-151 Reference ranges for our laboratory in normal subjects older than 65 years; n=33, except for ionised calcium.