The neurological conditions and anti-Hu antibody titre of PEM/PSN and non-PEM/PSN patients
| Patient number | Type of cancer | Neurological symptoms | Anti-Hu antibody titre |
|---|---|---|---|
| PEM/PSN: | |||
| 1 | SCLC | BE, En, My, SMN | 102400 |
| 2 | None known | BE, En, My, SMN, hearing loss | 102400 |
| 3 | None known | AN, BE, My, SMN | 102400 |
| 4 | Prostate | BE, LES, SCD | 102400 |
| 5 | Undifferentiated mediastinum | SMN, hearing loss | 25600 |
| 6 | SCLC | SN | 25600 |
| 7 | SCLC | BE, En, SCD | 102400 |
| 8 | SCLC | AN, BE, SMN | 819200 |
| Non-PEM/PSN: | |||
| 9 | SCLC | No neurological disturbance | 6400 |
| 10 | SCLC | No neurological disturbance | 6400 |
| 11 | SCLC | No neurological disturbance | 6400 |
| 12 | SCLC | No neurological disturbance | 51200 |
| 13 | SCLC | No neurological disturbance | 12800 |
| 14 | SCLC | No neurological disturbance | 102400 |
PEM/PSN=paraneoplastic encephalomyelitis/paraneoplastic sensory neuronopathy; non-PEM/PSN=small cell lung cancer without neurological disturbances; SCLC=small cell lung cancer; BE=brainstem encephalitis; En=encephalitis; My=myelitis; SMN=sensorimotor neuropathy; AN=autonomic neuropathy; LES=Lambert-Eaton syndrome; SCD=subacute cerebellar degeneration; SN=sensory neuronopathy. The titre was defined as the greatest dilution of each serum that stained the band of full length GST-HuD fusion protein on western blot. The medians (25 percentile, 75 percentile) of the anti-Hu antibody titre are 102400 (64000, 102400) in PEM/PSN patients and 9600 (6400, 51200) in non-PEM/PSN patients respectively.