Characteristics of patients stopping topiramate before and after 120 days
| Variable | More than 120 days (n=48) | Less than 120 days (n=42) | Significance | |
|---|---|---|---|---|
| Maximum dose | Mean (95% CI) | 349.0 (305.1 to 392.8) | 203.6 (178.7 to 228.5) | p < 0.0001† |
| Reason for stopping | Adverse events | 13 | 36 | OR =14.773-165 (55.44 to 4.98) |
| Ineffective and/or adverse events | 27 | 3 | OR = 0.0693-165 (0.24 to 0.012) | |
| Seizures worse and/or adverse events | 8 | 3 | OR = 0.42 (1.77 to 0.074) |
†Mean difference=145.39 (95% CI=195.31 to 96.47),t=5.80, p<0.0001.
↵3-165 Odds ratio significance p< 0.0001.