Distribution of characteristics of study population with or without deep white matter lesions (DWMLs)
| DWMLs (+) (n=77) | DWMLs (−) (n=101) | p Value | |
|---|---|---|---|
| Age (y) | 78.1 (5.8) | 75.6 ± 5.5 | 0.003 |
| Sex (M/F) | 15/62 | 22/79 | NS |
| Hypertension (+) | 37 (48%) | 32 (32%) | 0.026 |
| SBP (mm Hg) | 155 ( 25) | 148 ( 22) | 0.042 |
| DBP (mm Hg) | 77 (10) | 74 (10) | 0.052 |
| Diabetes mellitus (+) | 4 (5%) | 4 (5%) | NS |
| Hyperlipidaemia (+) | 19 (25%) | 21 (21%) | NS |
| Heart disease (+) | 5 (6%) | 12 (12%) | NS |
| Abnormal ECG1-150 (+) | 14 (18%) | 25 (25%) | NS |
| Alcohol consumption (+) | 15 (19%) | 16 (16%) | NS |
| Smoking (+) | 8 (10%) | 9 (9%) | NS |
| History of stroke (+) | 6 (8%) | 2 (2%) | NS |
| Focal signs (+) | 4 (5%) | 8 (8%) | NS |
| Gait disturbance (+) | 2 (3%) | 2 (2%) | NS |
| Brain infarction (+) | 27 (35%) | 21 (21%) | 0.034 |
| (No per case) | 2.15 (1.94) | 1.24 ( 0.63) | 0.044 |
| Blood chemistry: | |||
| Packed cell volume | 0.37 (0.04) | 0.37 (0.04) | NS |
| Albumin (g/l) | 42.1 (3.2) | 42.8 (2.5) | NS |
| Fasting blood glucose (mmol/l) | 5.13 (0.56) | 5.00 (0.53) | NS |
| Total cholesterol (mmol/l) | 5.08 (0.87) | 4.98 (0.94) | NS |
| HDL cholesterol (mmol/l) | 1.52 (0.33) | 1.46 (0.39) | NS |
| Creatinine (μmol/l) | 63.6 (14.1) | 62.8 (15.9) | NS |
| Uric acid (μmol/l) | 291 (88) | 272 (81) | NS |
| Amino acids: | |||
| Tryptophan (μmol/l) | 53.7 (10.9) | 58.3 (9.1) | 0.003 |
| Tyrosine (μmol/l) | 62.0 (10.8) | 65.2 (11.7) | 0.067 |
| Phenylalanine (μmol/l) | 56.3 (9.3) | 56.4 (7.3) | NS |
| Valine (μmol/l) | 178.60 (32.10) | 183.40 (29.60) | NS |
| Isoleucine (μmol/l) | 48.50 (8.80) | 49.80 (10.20) | NS |
| Leucine (μmol/l) | 94.50 (17.90) | 96.70 (18.20) | NS |
| Glutamic acid (μmol/l) | 31.5 (10.6) | 31.5 (10.8) | NS |
| Glutamine (μmol/l) | 610.4 (74.2) | 615.0 (72.1) | NS |
| Glycine (μmol/l) | 235.7 (70.10) | 235.6 (59.9) | NS |
| Arginine (μmol/l) | 81.1 (16.3) | 81.0 (14.8) | NS |
| Taurine (μmol/l) | 55.4 (14.8) | 53.0 (10.3) | NS |
SBP=Systolic blood pressure; DBP=diastolic blood pressure; DWML=deep white matter lesion; values are mean (SD); NS=not significant (p>0.1).
↵1-150 Left ventricular hypertrophy, ischaemic change, or atrial fibrillation.