Baseline characteristics of study groups
| Parameter | Phenytoin | Valproate | Total |
|---|---|---|---|
| No of cases | 50 | 50 | 100 |
| Men/women | 26 / 24 | 21 / 29 | 47 / 53 |
| Mean age/ range (y) | 55 / 21–78 | 51 / 21–77 | 53 / 21–78 |
| Completed 12 months | 29 (27) | 31 (28) | 60 (55) |
| Pathology: | |||
| Malignant glioma | 7 (0) | 11 (2) | 18 (2) |
| Low grade glioma | 2 (1) | 1 (1) | 3 (2) |
| Metastasis | 9 (2) | 4 (1) | 13 (3) |
| Meningioma | 7 (6) | 8 (7) | 15 (13) |
| Other tumours1-150 | 4 (4) | 4 (4) | 8 (8) |
| Traumatic head injury | 2 (1) | 2 (1) | 4 (2) |
| Chronic subdural haematoma | 1 (0) | 2 (2) | 3 (2) |
| Intracranial haemorrhage | 3 (2) | 1 (1) | 4 (3) |
| Aneurysmal SAH | 15 (11) | 13 (5) | 28 (16) |
| Cavernoma | 0 (0) | 4 (4) | 4 (4) |
↵1-150 Other brain tumors were a pituitary adenoma, neurocytoma, schwannoma, and a haemangioblastoma in the phenytoin group, and two colloid cysts, a pitiutary adenoma, and a hamartoma in the valproate group. SAH=Subarachnoid haemorrhage. The number of patients with complete cognitive assessment are shown in parentheses..