Case/ age (y)/ sex | Duration of dementia (y) | Fixed brain weight (g) | Neuritic pathology stage | Amyloid plaque stage | CAA stage lm c | Lewy bodies b/s cortical | Diffuse white matter pathology stage | Focal infarcts | Combined CVD (focal and diffuse) stage | ApoE genotype | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1/80/F | 2 | 1270 | 6 | C | 1 | O | − | − | Ι | — | Ι | 2/4 |
2/85/F | 5 | 1275 | 3 | C | 2 | Ι | + | − | Ι | Multiple, subacute, small infarcts in R.MCA territory | ΙΙ | 3/3 |
3/89/M | 5 | 1305 | 5 | C | 2 | Ι | − | − | ΙΙ | — | ΙΙ | 3/4 |
4/79/F | 4 | 1330 | 4 | C | 2 | Ι | − | − | ΙΙ | 1 lacune in pons; 1 occipital cortical micoinfarct | ΙΙΙ | 3/4 |
5/86/M | 11-150 | 1443 | ⩽2 | B | 0 | O | + | + | ΙΙ | Small hippocampal CA1 infarct | ΙΙΙ | 3/4 |
6/86/M | 2 | 1317 | 4 | B | 1 | Ι | − | − | Ι | — | Ι | 3/4 |
7/77/M | 7 | 1371 | 4 | O | 1 | Ι | − | − | ΙΙ | — | ΙΙ | 3/4 |
8/74/M | 3 | 1183 | 4 | C | 1 | O | − | − | ΙΙ | — | ΙΙ | — |
9/82/F | NK | 1035 | 4 | C | 1 | Ι | − | − | Ι | — | Ι | 3/4 |
10/75/F | NK | 1370 | 4 | C | 2 | Ι | + | + | Ι | 1 type 1b lacune in putamen | ΙΙ | 3/4 |
11/90/F | NK | 1239 | 4 | C | 1 | O | − | − | Ι | Putamen:one type 1a lacune and type 1b lacunes | ΙΙ | — |
12/63/M | 5 | 1359 | 6 | C | 1 | Ι | + | + | Ι | — | Ι | 3/3 |
13/83/M | 1 | 1331 | 4 | C | 3 | ΙΙ | − | − | ΙΙ | Occasional cortical micro infarcts; 1lacune in putamen and 1 in thalamus | ΙΙΙ | 3/4 |
14/95/F | 1 | 1205 | 3 | C | 1 | Ι | − | − | ΙΙΙ | — | ΙΙΙ | 3/4 |
15/80/M | 1.5 | 1471 | 5 | C | 3 | ΙΙ | − | − | ΙΙ | — | ΙΙ | 3/3 |
16/82/F | 1.5 | 1254 | 4 | C | 1 | Ι | − | − | Ι | Small cerebellar border zone infarcts (recent); frontal subcortical lesion | ΙΙ | 3/4 |
17/67/M | 14 | 1004 | 6 | B | 1 | Ι | − | − | Ι | — | Ι | 3/3 |
Case/ age (y)/ sex | Duration of dementia (y) | Fixed brain weight (g) | Neuritic pathology stage | Amyloid plaque stage | CAA stage 1/m c | Lewy bodies b/s cortical | Diffuse white matter pathology stage | Focal hypoxic-ischaemic lesions | Combined CVD (focal and diffuse) stage | ApoE genotype | ||
18/78/M | 21-150 | 1560 | ⩽2 | B | 3 | Ι | + | + | Ι | 1 frontal cortical microinfarct | ΙΙ | 3/3 |
19/92/F | Long standing | 1098 | 4 | C | 3 | ΙΙ | − | − | ΙΙ | Several type 1b lacunes in putamen | ΙΙΙ | 4/4 |
20/84/F | 6 | 1232 | 4 | C | 1 | O | + | + | ΙΙ | — | ΙΙ | 3/3 |
21/81/M | 7 | 1301 | 5 | C | 1 | Ι | − | − | Ι | — | Ι | — |
22/80/M | 1 | 1270 | 3 | B | 1 | ΙΙ | + | + | Ι | — | Ι | 3/4 |
23/82/F | 2 | 1102 | 4 | C | 0 | O | − | − | Ι | Type 1b lacunes in thalamus; acute bg infarct | ΙΙ | 3/3 |
24/77/F | Long standing | 1137 | 3 | B | 2 | Ι | + | + | ΙΙ | 1 type 1b lacune in putamen. | ΙΙΙ | 4/4 |
25/71/M | 4 | 1574 | 5 | B | 2 | Ι | − | − | ΙΙ | Multiple cortical microinfarcts; type 1b lacunes in thalamus and putamen; type 1a lacunes in putamen and pons | ΙΙΙ | 3/3 |
ApoE = apolipoprotein E; bg = basal ganglia; b/s=brain stem; c=cortical vessels; CAA=cerebral amyloid angiopathy; CVD=cerebrovascular disease; L=left; lm=leptomeningeal vessels; MCA=middle cerebral artery; NK=not known; R=right; +/−=present/absent.
↵1-150 = Parkinsonism.