Table 5

Cost, quality adjusted life-year, and cost effectiveness estimates from different models

Standard care Drug therapy Difference
5 Year model with no effect on progression
Relapses5.233.711.52
Undiscounted costs:
 Relapses£11000£7800£3200
 IFβ-1b£0£52500£52500
 Total costs£11000£60300£49300
Cost per relapse avoided£32400
Discounted costs:
 Relapse£10000£7100£2900
 IFβ-1b£0£46600£46600
 Total cost£10000£53600£43600
Cost per relapse avoided£28700
QALY gain:
 Undiscounted−0.204−0.1450.059
 Discounted−0.184−0.1300.054
Cost per QALY gained:
 Undiscounted£831400
 Costs only discounted£736200
 Costs and QALYs discounted£809900
5 Year model with effect on progression
Costs£15200£58600£43400
QALY gain3.083.210.13
Cost per QALY gained£328300
10 Year model with effect on progression: base case
Costs£29900£104700£74800
QALY gain5.325.650.33
Cost per QALY gained£228300
10 Year model with effect on progression: best case
Costs£29900£102200£72300
QALY gain5.256.230.98
Cost per QALY gained£74500
10 Year model with effect on progression - worst case
Costs£29900£105400£75500
QALY gain5.325.450.13
Cost per QALY gained £604600