Characterisation of the employed Abs and distribution of the recognized isoforms.
| Anti-FN mAbs4 5 | Anti-TN Ab fragments3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IST-4 | IST-9 | BC-1 | TN-12 | TN-11 | ||||||||
| Recognised isoforms | Total FN | Isoforms containing the ED-A sequence | Isoform containing the ED-B sequence | Total TN | Type III repeat C Isoform | |||||||
| Distribution of the isoform (s) | Widespread | Widespread | Absent in adult tissues (with the exception of the regenerating endometrium) | Widespread | Absent in adult tissues | |||||||
| Present in fetal tissues | ||||||||||||
| Present in the vascular wall and the matrix of fetal tissues and tumours | Absent in several types of malignancies | |||||||||||
| Present in the vascular wall of anaplastic gliomas | ||||||||||||