Corticospinally mediated excitatory (hand and leg muscles) and callosally mediated inhibitory (hand muscles) motor effects in 50 MS patients and in 25 normal subjects
| Muscle | Parameter | Normal subjects 50 hands and 50 legs | Limits of normal range | MS patients 100 hands and 100 legs | Abnormal responses (muscles/patients) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Range | Mean (SD) | Range | ||||||||
| FDI | Central motor latency (ms) | 6.7 (1.0) | 4.6–9.2 | <9.2 (<mean+2.5 SD) | 7.3 (1.6) | 4.8–12.01-150 | 10/7 | ||||
| Amplitude (mV) | 7.6 (1.4) | 4.0–10.6 | >4.0 (>lowest value) | 5.7 (2.3) | 0.8–10.01-160 | 24/17 | |||||
| Latency of TI (ms) | 35.7 (3.2) | 29.8–43.0 | <43.9 (<mean+2.5 SD) | 36.9 (4.5) | 27.4–50.4 | 10/9 | |||||
| Duration of TI (ms) | 24.9 (3.0) | 19.6–32.2 | <32.6 (<mean+2.5 SD) | 34.8 (10.9) | 10.0–69.81-160 | 51/36 | |||||
| Transcallosal conduction time (ms) | 15.3 (2.7) | 9.0–20.8 | <22.2 (<mean+2.5 SD) | 15.6 (3.6) | 7.0–24.4 | 2/2 | |||||
| TA | Central motor latency (ms) | 14.2 (2.1) | 10.0–19.0 | <19.4 (<mean+2.5 SD) | 19.0 (5.3) | 11.2–33.41-160 | 40/24 | ||||
| Amplitude (mV) | 4.2 (2.2) | 1.0–11.6 | >1.0 (>lowest value) | 3.2 (2.1) | 0.3–8.31-160 | 3/3 | |||||