Drug history of patients treated with vigabatrin
| Patient | VGB duration (y) | Cumulative VGB dose (kg) | Max VGB dose (g/d) | Previous drugs | Concurrent drugs |
|---|---|---|---|---|---|
| 1 | 1.9 | 1.8 | 4.0 | TMO, PRM, OSP, CBZ, | PHT, VPA |
| 2 | 7.1 | 3.9 | 1.5 | PRM | PHT, CBZ, GBP |
| 3 | 3.2 | 1.3 | 2.0 | VPA, CBZ | — |
| 4 | 5.8 | 6.4 | 3.5 | CBZ, VPA, PRM, ACE, LTG | BZD, GBP |
| 5 | 5.4 | 2.7 | 1.5 | PRM, CBZ, VPA | PHT, LTG |
| 6 | 5.5 | 6.8 | 3.0 | PRM, PHT, CBZ, VPA | — |
| 7 | 5.0 | 4.4 | 3.0 | CBZ, BZD | PHT, VPA |
| 8 | 4.9 | 7.0 | 4.0 | PRM | PHT |
| 9 | 1.7 | 2.7 | 5.0 | CBZ | LTG, ACE |
| 10 | 4.5 | 5.5 | 3.5 | PRM, PHT, OSP, CBZ | VPA |
| 11 | 3.4 | 1.8 | 3.0 | PHT | CBZ |
| 12 | 8.2 | 8.9 | 3.0 | PRM, ESM, PHT | CBZ |
| 13 | 7.8 | 10.3 | 4.0 | VPA, ACE | CBZ |
| 14 | 5.1 | 3.6 | 2.0 | PRM, OSP, VPA | PHT, CBZ, LTG |
| 15 | 6.1 | 3.1 | 1.5 | PHT, ESM, VPA, BZD, PRM | CBZ |
| 16 | 2.9 | 3.5 | 4.0 | PHT, VPA | CBZ |
| 17 | 5.5 | 7.1 | 4.0 | VPA, CBZ, GBP | PHT, LTG |
| 18 | 2.3 | 2.3 | 3.0 | PRM, CBZ, PHT, BZD, GBP | VPA |
| 19 | 5.8 | 4.8 | 2.5 | — | CBZ |
| 20 | 0.9 | 0.7 | 3.5 | PRM, PHT | CBZ, VPA |
| 21 | 1.5 | 0.6 | 1.5 | PHT, VPA, LTG | CBZ |
| 22 | 3.1 | 2.2 | 3.0 | PRM, PHT, CBZ | VPA |
| 23 | 5.3 | 2.5 | 3.0 | PHT, VPA, PRM, BZD, LTG | CBZ, GBP |
| 24 | 1.3 | 1.3 | 4.0 | PRM, PHT, LTG | CBZ |
| 25 | 0.8 | 0.7 | 2.0 | VPA, PHT | CBZ, BZD |
PRM=primidone and barbiturates; PHT=phenytoin; CBZ=carbamazepine; VPA=sodium valproate; BZD=benzodiazepines; LTG=lamotrigine; GBP=gabapentin; ESM=ethosuximide; ACE=acetazolamide; OSP=ospolot; TMO=trimethadione; TOP=topiramate.