Diagnostic criteria of hedonistic homeostatic dysregulation syndrome due to dopamine replacement therapy misuse
| (A) | Parkinson's disease with documented levodopa responsiveness |
| (B) | Need for increasing doses of DRT in excess of those normally required to relieve Parkinsonian symptoms and signs |
| (C) | Pattern of pathological use: expressed need for increased DRT in the presence of excessive and significant dyskinesias despite being ‘on’, drug hoarding or drug seeking behaviour, unwillingness to reduce DRT, absence of painful dystonias |
| (D) | Impairment in social or occupational functioning: fights, violent behaviour, loss of friends, absence from work, loss of job, legal difficulties, arguments or difficulties with family |
| (E) | Development of hypomanic, manic, or cyclothymic affective syndrome in relation to DRT |
| (F) | Development of a withdrawal state characterised by dysphoria, depression, irritability, and anxiety on reducing the level of DRT. |
| (G) | Duration of disturbance of at least 6 months |