Table 1

Clinical data of patients with acute myelitis after asthma attacks

Patient 1 Patient 2 Patient 3
Age at onset/sex15/Male22/Female73/Female
Serum total IgE (U/ml)1300298306
Eosinophil (%)8%6.5%8.7%
Interval between asthma attack and
onset of myelitis (days)
67 (1') and 9 (2')1-150 2
Symptoms and signs during illness:
 Motor weakness+ (mono)+ (mono)+ (mono)
 Muscle atrophy+++
 Increased tendon reflex+ (2')+
 Sensory signs+
 Sphincter disturbance
Clinically estimated main lesionsLSLS (1'), C (2')C
EDSS33.53
Spinal cord MRI+ (C, 2')
Needle EMGNeurogenic changesNeurogenic changesNeurogenic changes
(myotomes)1-151 (lt L2-S1, rt L2-L4)(rt L2-S2)(rt C5-T1)
CSF:
 Pleocytosis (>5/μl)711
 Increased protein (>45 mg/dl)545240
Clinical courseUnimprovedSlightly improvedUnimproved
  • 1-150 Patient 2 had a second asthma attack during the corticosteroid therapy and 9 days later she developed another episode of monoparesis.

  • 1'=the first episode; 2'=the second episode.

  • C=Cervical; T=thoracic; LS=lumbosacral; mono=monoparesis; EDSS=Kurtzke's expanded disability status scale.16

  • 1-151 Myotomes showing neurogenic changes on needle EMG; lt=left; rt=right.