Table 3

Sensitivity of biomarkers relative to AUDIT at 80% and 90% specificity. Data derived from ROC analyses. Clinician's ability to identify cases is inserted for comparison

no of
cases
Sensitivity (%)
at 80% specificity
Sensitivity (%)
at 90% specificity
AUC (95% CI) Best cut
off value
All cases:
 Clinicians' scores13366620.78  (0.70–0.85)1
 CDT15043350.67 (0.59–0.75)5.4
 GT15826250.57 (0.49–0.65)44
 ASAT15740300.67 (0.59–0.74)26
 ALAT 15725210.63 (0.55–0.70)28
 ASAT/ALAT ratio1481740.54 (0.45–0.62)0.79
Men:
 Clinicians' scores7572690.84 (0.73–0.91)0
 CDT8362480.78 (0.67–0.83)6.6
 GT8331310.58 (0.46–0.69)112
 ASAT8237310.66 (0.54–0.76)25
 ALAT8228230.63 (0.51–0.73)
 ASAT/ALAT ratio821790.54 (0.46–0.63)0,76
Women:
 Clinicians' scores5955500.71 (0.58–0.82)1
 CDT7128220.52 (0.40–0.64)
 GT751760.51 (0.39–0.63)
 ASAT7550280.66 (0.54–0.77)26
 ALAT7522170.57 (0.45–0.69)26
 ASAT/ALAT ratio751160.58 (0.46–0.70)0.86
  • AUC= Area under the ROC curve.