Frequencies of the ACE and ecNOS polymorphisms in patients with Alzheimer's disease, healthy controls younger than 65 years, and healthy controls older than 85 years.
| ACE | ecNOS | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotypes | Alleles# | Genotypes | Alleles | ||||||||||
| DD | ID | II | D | I | 55 | 45 | 44 | 5 | 4 | ||||
| Patients (%) | 119 (34) | 161 (46) | 70 (20) | 0.57 | 0.43 | 273 (78) | 70 (20) | 7 (2) | 0.85 | 0.15 | |||
| Mean age (SD) | 72 (9) | 72 (8) | 72 (7) | 71 (10) | 72 (9) | 71 (8) | |||||||
| Controls (%) | 164 (41) | 176 (44) | 60 (15) | 0.62 | 0.38 | 296 (74) | 97 (24) | 7 (2) | 0.86 | 0.14 | |||
| Controls >85 (%) | 43 (37) | 58 (49) | 16 (14) | 0.62 | 0.38 | 86 (73) | 29 (25) | 2 (2) | 0.86 | 0.14 | |||
In addition to the four and five repeat ecNOS alleles, there were also two rare alleles of three and six repeats Two patients were ecNOS-56 and three controls were ecNOS-35). The ACE-I allele was at a significantly higher frequency in patients (Yates' χ2, p=0.03, OR=1.28 (95% CI 1.04-1.58)