Percentages of moderate and severe degree of white matter changes and cerebral atrophy in patients with and without prestroke cognitive decline in the Helsinki Stroke Aging Memory (SAM) Study Cohort (n=337)
| No cognitive decline prestroke (n=306) | Cognitive decline prestroke (n=31) | All (n=337) | p Value | |
|---|---|---|---|---|
| White matter changes: | ||||
| Periventricular | 52.5 | 72.4 | 54.3 | 0.0404 |
| Centrum semiovale | 20.8 | 44.8 | 22.9 | 0.0032 |
| Watershed areas | 32.2 | 48.3 | 33.6 | 0.0805 |
| Subcortical | 8.1 | 6.9 | 8.0 | 0.8147 |
| Mean Fazekas white matter score (SD) | 3.1 (1.5) | 4.0 (1.7) | 3.2 (1.5) | 0.0037 |
| Cortical atrophy: | ||||
| Frontal | 36.8 | 62.1 | 39.1 | 0.0078 |
| Parietal | 41.2 | 58.6 | 42.3 | 0.0706 |
| Occipital | 41.2 | 48.3 | 41.9 | 0.4620 |
| Entorhinal | 21.0 | 69.0 | 25.2 | 0.0000 |
| Hippocampal | 15.5 | 55.2 | 19.1 | 0.0000 |
| Medial temporal | 22.0 | 69.0 | 26.2 | 0.0000 |
| Central atrophy: | ||||
| Temporal | 28.0 | 65.5 | 31.4 | 0.0000 |
| Frontal | 35.1 | 65.5 | 37.1 | 0.0013 |
| Lateral | 38.9 | 65.5 | 41.2 | 0.0054 |
| Occipital | 41.9 | 75.9 | 44.9 | 0.0004 |