MMP-9, MMP-3, and TIMP-1 concentrations, white blood cell count, and total protein concentrations in the CSF of patients with acute neuroborreliosis and controls with non-inflammatory neurological disorders
| CSF parameter | Patients with acute neuroborreliosis (n=31) | Patients with non-inflammatory neurological disorders (n=20) |
| MMP-9 concentrations (ng/ml) | 13.2 (29.3)1-150 | 1.0 (0.0) |
| MMP-3 concentrations (ng/ml) | 7.5 (12.2) | 3.8 (0.0) |
| TIMP-1 concentrations (ng/ml) | 230.7 (142.4)1-150 | 109.7 ( 112.7) |
| White blood cell count (cells/μl) | 576 (613)1-150 | 1 (1) |
| Total protein content (mg/dl) | 413 (517)1-150 | 42 (17) |
Values in parentheses are SD. Concentrations were calculated using a standard curve. The detection limit in the CSF was 1 ng/ml for MMP-9, and 3.75 ng/ml for MMP-3 and TIMP-1. The ELISA system is designed to detect the proform of MMPs in both the free and the complexed form with TIMPs.
↵1-150 p<0.05, compared with CSF parameters from patients with non-inflammatory neurological disorders.