| Measure | Pre-PVP | 3 month Post-PVP | Pre to 3 months p Value | 12 month Post-PVP | Pre to 12 months p Value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Right Mean (SD) | Left Mean (SD) | Total Mean (SD) | Right Mean (SD) | Left Mean (SD) | Total Mean (SD) | Right Mean (SD) | Left Mean (SD) | Total Mean (SD) | |||||
| H and Y staging (I–V) | |||||||||||||
| On | 2.69 (0.60) | 2.62 (0.75) | 2.66 (0.12) | 1.69 (0.66) | 1.79 (0.76) | 1.74 (0.12) | 0.01** | 1.73 (0.97) | 1.78 (0.74) | 1.75 (0.14) | 0.01** | ||
| Off | 4.00 (0.71) | 4.00 (0.66) | 4.00 (0.12) | 2.65 (0.56) | 2.85 (0.70) | 2.75 (0.11) | 0.01** | 2.65 (0.56) | 3.02 (0.75) | 2.84 (0.12) | 0.01** | ||
| UPDRS Total (0–199) | |||||||||||||
| On | 46.8 (9.0) | 44.4 (14.1) | 46.2 (2.0) | 20.6 (6.0) | 23.9 (11.1) | 22.3 (1.6) | 0.01** | 21.6 (9.8) | 23.7 (10.7) | 22.9 (1.7) | 0.01** | ||
| Off | 88.2 (19.2) | 85.9 (17.5) | 87.1 (3.0) | 47.6 (12.2) | 50.9 (15.7) | 49.3 (2.5) | 0.01** | 47.0 (11.4) | 52.1 (14.7) | 49.5 (2.3) | 0.01** | ||
| UPDRS Motor (0–144) | |||||||||||||
| On | 29.5 (8.1) | 28.8 (10.7) | 29.1 (1.7) | 13.8 (4.8) | 15.4 (8.9) | 14.6 (1.3) | 0.01** | 14.7 (8.0) | 14.8 (7.0) | 14.8 (1.2) | 0.01** | ||
| Off | 55.6 (16.3) | 55.0 (13.1) | 55.3 (2.4) | 31.8 (9.2) | 32.6 (11.4) | 32.2 (1.8) | 0.01** | 30.5 (8.1) | 33.3 (11.1) | 31.9 (1.7) | 0.01** | ||
| UPDRS ADL (0–51) | |||||||||||||
| On | 15.5 (4.4) | 15.7 (4.8) | 15.6 (0.78) | 7.15 (4.0) | 7.90 (3.7) | 7.53 (0.63) | 0.01** | 6.85 (2.8) | 8.07 (3.4) | 7.46 (0.53) | 0.01** | ||
| Off | 29.6 (6.7) | 30.9 (5.7) | 30.3 (1.0) | 16.2 (5.7) | 18.3 (5.4) | 17.3 (0.91) | 0.01** | 16.2 (3.7) | 18.6 (4.8) | 17.4 (0.75) | 0.01** | ||
| S and E ADL (0%–100%) | |||||||||||||
| On | 78.5 (8.0) | 75.3 (12.6) | 76.9 (1.9) | 89.6 (8.0) | 89.1 (7.1) | 89.4 (1.2) | 0.01** | 87.7 (12.5) | 89.3 (7.0) | 88.5 (1.5) | 0.01** | ||
| Off | 43.1 (13.2) | 44.5 (14.3) | 43.8 (2.3) | 67.3 (10.5) | 63.6 (16.8) | 65.5 (2.5) | 0.01** | 66.9 (10.3) | 60.1 (15.4) | 63.5 (2.4) | 0.01** | ||
| Levodopa total daily dose (mg)3-154 | 481 (306) | 463 (212) | 468 (241) | 587 (329) | 500 (315) | 526 (318) | 0.19 | 613 (368) | 515 (406) | 545 (393) | 0.16 | ||
↵3-151 No significant differences between right and left pallidotomy patients on neurological variables;
↵3-152 time factor significant at p<0.01 for all variables unless noted;
↵3-153 3 months did not differ significantly from 12 months on any neurology measure;
↵3-154 p<0.18.
ADL=Activities of daily living; H and Y=Hoehn and Yahr staging, higher number indicates more impairment; S and E=Schwab and England activities of daily living scale, higher number indicates more independence; UPDRS=united Parkinson's disease rating scale, higher number indicates more impairment.