Measure | Patient 1 | Patient 2 | Patient 3 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre Raw (SD)4-152 | 3 months Raw (SD) | 12 months Raw (SD) | Pre Raw (SD) | 3 months Raw (SD) | 12months Raw (SD) | Pre Raw (SD) | 3 months Raw (SD) | 12 months Raw (SD) | ||||||||||||||
MMSE | 28 | 28 | 27 | 27 | 27 | 29 | 29 | 26 | 27 | |||||||||||||
CVLT Total | 29 (−2.1) | 24 (−3.2) | 22 (−3.4) | 39 (−1.2) | 30 (−2.8) | 31 (−2.2) | 61 (0.60) | 53 (−0.30) | 52 (−0.40) | |||||||||||||
↓−1.1 | ↓−1.3 | ↓−1.6 | ↓−1.0 | |||||||||||||||||||
COWAT | 28 (−0.30) | 20 (−1.7) | 18 (−2.0) | 43 (0.60) | 26 (−1.2) | 19 (−2.0) | 19 (−0.68) | 18 (−0.72) | 21 (−0.40) | |||||||||||||
↓−1.4 | ↓−1.7 | ↓−1.8 | ↓−2.6 | |||||||||||||||||||
SDMT | 35 (−2.2) | 24 (−3.4) | 21 (−3.8) | 35 (−2.2) | 25 (−3.3) | 27 (−3.1) | 30 (−2.1) | 21 (−3.0) | 29 (−2.2) | |||||||||||||
↓−1.2 | ↓−1.6 | ↓−1.1 | ||||||||||||||||||||
Trails A | 71 (−3.5) | 42 (−0.65) | 55 (−1.9) | 46 (−1.3) | 48 (−1.5) | 38 (−0.39) | 49 (−0.64) | 80 (−3.0) | 73 (−2.5) | |||||||||||||
↑−2.9 | ↑−1.6 | ↓2.4 | ↓−1.86 | |||||||||||||||||||
Trails B | 151 (−2.8) | 288 (−8.0) | 257 (−6.9) | 147 (−2.2) | 164 (−2.8) | 200 (−4.2) | 154 (−2.5) | 199 (−4.1) | 146 (−2.2) | |||||||||||||
↓−5.2 | ↓−4.1 | ↓−2.0 | ↓−1.6 | |||||||||||||||||||
WCST Total errors | 59 (−1.3) | 84 (−2.5) | 72 (−2.0) | 55 (−.57) | 61 (−0.93) | 60 (−0.86) | 51 (−0.95) | 51 (−0.95) | 52 (−1.0) | |||||||||||||
↓−1.2 | ||||||||||||||||||||||
BDI | 1 | 1 | 3 | 4 | 4 | 8 | 12 | 15 | 6 |
↵4-150 BNT, CVLT long delay, Hooper, and Stroop interference did not decline greater than 1 SD for three patients;
↵4-151 see table 2 for description of variables measured;
↵4-152 SDs are based on published test norms (see table 2 for references); ↓=decline from baseline ⩾1 SD; ↑=improvement from baseline⩾1 SD.