PP MS according to presenting symptom
| Year | Cord presentation (112) | Other (25) | ||
| EDSS | 0 Median | 6.00 (2.0–8.5)2-150 | 6.00 (2.0–8.5) | |
| 1 Median | 6.00 (2.0–9.0) | 6.00 (2.5–9.0) | ||
| Definite deterioration | 31 (28%) patients | 4 (16%) patients | ||
| New brain lesions | Mean | 0.97 (SD 1.65) | 0.50 (SD 1.06) | |
| Median | 0.00 (0–9) | 0.00 (0–4) | ||
| Brain T2 load (cm3) | 0 Mean | 9.67 (SD 10.97) | 20.96 (SD 21.30) | |
| Median | 6.23 (0–62.60)2-150 | 15.43 (0.2–72.20)2-150 | ||
| 1 Mean | 10.98 (SD 12.46) | 23.17 (SD 23.86) | ||
| Median | 6.29 (0–57.79) | 15.87 (0.15–74.73) | ||
| Change | Mean | 1.31 (SD 3.43) [17.6%] | 2.22 (SD 4.82) [8.28%] | |
| Median | 0.30 (−6.0–18.8) [7.8%] | 1.09 (−3.6–20.3) [6.3%] | ||
| Brain T1 load (cm3) | 0 Mean | 3.67 (SD 6.10) | 7.26 (SD 7.45) | |
| Median | 1.34 (0–33.30)2-150 | 5.95 (0–26.19) | ||
| 1 Mean | 3.90 (SD 5.91) | 7.65 (SD 6.66) | ||
| Median | 1.68 (0–32.9) | 7.34 (0–21.87) | ||
| Change | Mean | 0.24 (SD 1.70) [25.7%] | 0.39 (SD 3.16) [26.2%] | |
| Median | 0.09 (−5.6–11.3) [11.7%] | 0.67 (−10.2–5.6) [18.4%] | ||
| 6 Slice brain volume (cm3) | 0 Mean | 268.79 (SD 23.22) | 261.77 (SD 23.09) | |
| Median | 271.40 (212.8–320.6)2-150 | 262.12 (210.3–305.8)2-150 | ||
| 1 Mean | 265.43 (SD 24.51) | 257.95 (SD 22.96) | ||
| Median | 266.73 (203.4–315.3) | 255.83 (208.2–299.5) | ||
| Change | Mean | −3.35 (SD 7.4) [−1.27%] | −3.82 (SD 3.92) [−1.46%] | |
| Median | −2.22 (−45.6–11.2) [−0.82%] | −3.14 (−10.1–3.5) [−1.19%] | ||
| Number of cord lesions | 0 Mean | 2.10 (SD 2.60) | 2.61 (SD 2.42) | |
| Median | 1.00 (0–12)2-150 | 2.00 (0–7) | ||
| 1 Mean | 2.24 (SD 2.59) | 2.70 (SD 2.47) | ||
| Median | 2.00 (0–12) | 2.00 (0–7) | ||
| New cord lesions | Mean | 0.14 (SD 0.35) | 0.08 (SD 0.27) | |
| Median | 0.00 (0–1) | 0.00 (0–1) | ||
| Cord lesion load | 0 Mean | 2.62 (SD 3.32) | 3.30 (SD 4.31) | |
| Median | 1.50 (0–16)2-150 | 1.50 (0–18.5) | ||
| 1 Mean | 2.78 (SD 3.32) | 3.42 (SD 4.36) | ||
| Median | 1.50 (0–16) | 1.50 (0–18.5) | ||
| Increase in cord load | Mean | 0.15 (SD 0.43) | 0.11 (SD 0.39) | |
| Median | 0.00 (0–2) | 0.00 (0–2) | ||
| Cord area (mm2) | 0 Mean | 73.03 (SD 9.89) | 72.39 (SD 9.03) | |
| Median | 73.62 (43.6–93.8)2-150 | 72.00 (49.9–90.8)2-150 | ||
| 1 Mean | 70.36 (SD 10.71) | 69.29 (SD 9.17) | ||
| Median | 71.00 (42.9–90.0) | 69.96 (48.8–87.4) | ||
| Change | Mean | −2.68 (SD 3.22) [−3.81%] | −3.10 (SD 2.73) [−4.31%] | |
| Median | −3.00 (−13.0–4.2) [−3.96%] | −2.86 (−11.8–1.7) [−4.10%] | ||
↵2-150 p<0.01, baseline v year 1 values.
Definite deterioration in the EDSS is defined as an increase of 1.0 if the EDSS ⩽5 or an increase of 0.5 if >5.0.
Wilcoxon signed ranks test used to assess differences between baseline and year 1. Mann-Whitney test used to detect differences between the patient groups in absolute and % change of MR parameters.