Seizure and antiepileptic drug (AED) details
| Topiramate group | Comparison group | ||||||
|---|---|---|---|---|---|---|---|
| Session 1 (no TPM) Median (range) | Session 2 (on TPM) Median (range) | Session 1 Median (range) | Session 2 Median (range) | ||||
| Seizure frequency (3 months pretesting): | |||||||
| Complex partial | 18 (6–120) | 9 (3–84)2-150 | 16.5 (6–36) | 14 (0–72) | |||
| Generalised tonic | 3 (1–18) | 1 (0–9)2-150 | 3 (1–30) | 2.5 (0–36) | |||
| Atonic | 6 | 0 | 12 | 12 | |||
| AEDs: | |||||||
| Median number taken | 2.3 | 2.6 | 2.0 | 2.3 | |||
| CBZ (median dose, No on drug and range) | 1300 (14) | 1600 (14) | 1000 (9) | 1200 (13) | |||
| 400–1800 | 400–2200 | 800–2000 | 600–1800 | ||||
| VPA | 2000 (6) | 1500 (7) | 1400 (11) | 1800 (6) | |||
| 1100–3000 | 500–2000 | 500–2000 | 1200–3000 | ||||
| PHT | 400 (4) | 300 (1) | 425 (6) | 400 (5) | |||
| 300–375 | 250–475 | 200–450 | |||||
| LTG | 300 (4) | None | 425 (4) | 400 (5) | |||
| 100–600 | 300–500 | 200–450 | |||||
| CLB | 10 (3) | 10 (3) | 10 (2) | 10 (5) | |||
| 10–30 | 5–10 | ||||||
| CLZ | 3 (1) | 2 (1) | 2 (1) | 9 (2) | |||
| 3–12 | |||||||
| GBP | 2100 (4) | None | 3600 (1) | 1200 (1) | |||
| 900–2500 | |||||||
| GVG | 2000 (3) | 2000 (1) | |||||
| Other | 4000 (1) | 250 (1) | 250 (1) | ||||
| LT | PMD | PMD | |||||
↵2-150 p<0.01.
CBZ=Carbamazepine; VPA=sodium valproate; PHT=phenytoin; LTG=lamotrigine; CLB=clobazam; CLZ=clonazepam; GBP = gapapentin; GVG=vigabatrin; LT=levetiracetam; PMD=primidone.