Table 4

Current genetic classification of hereditary spastic paraparesis

Genome database designation	Chromosome	Inheritance	Phenotype	Genetic defect
SPG1	Xq28	X—linked	Complicated	L1CAM
SPG2	Xq22	X—linked	Both	PLP
SPG3	14q11.2-24.3	AD	Pure	Unknown
SPG4	2p22-21	AD	Both	Spastin
SPG5	8p12-q13	AR	Pure	Unknown
SPG6	15q11.1	AD	Pure	Unknown
SPG7	16q24.3	AR	Both	Paraplegin
SPG8	8q24	AD	Pure	Unknown
SPG9	10q23.3-24.2	AD	Complicated	Unknown
SPG10	12q13	AD	Pure	Unknown
(SPG11)	15q13-15	AR	Both	Unknown

L1CAM=L1 cell adhesion molecule; PLP=proteolipid protein; AD=autosomal dominant; AR=autosomal recessive; ( )=genome database designation unconfirmed.