Table 2

Multivariate associations between smoking/drinking and incident cognitive impairment^2-150

		Crude				Adjusted model 1				Adjusted model 2
		RR	95% CI			p Value	RR			95% CI	p Value	RR	95% CI	p Value
Smoking			0.055				0.047				0.035
Never smoked	Base				Base				Base
Ex-smoker	0.74	0.3–2.1	0.6		0.98	0.3–3.3	0.96		0.86	2–2.9	0.81
Current smoker	2.3	0.8–6.3	0.07		3.6	0.99–13.5	0.048		4.07	1.01–16.3	0.047
Alcohol before the age of 65			0.54				0.58
0 units	Base				Base
1–10 units	0.75	0.3–1.9	0.55		0.74	0.2–2.1	0.58
11–30 units	0.25	0.3–2.0	0.19		0.21	0.1–1.9	0.17
30+ units	1.16	0.3–4.3	0.82		0.81	0.2–4.2	0.80
Alcohol after the age of 65			0.55								0.51
0 units	Base								Base
1–10 units	0.52	0.2–1.4	0.18						0.43	0.1–1.4	0.16
11–30 units	0.54	0.1–2.5	0.43						0.51	0.1–3.1	0.46
30+ units	0.01	0.0–6.2	0.76						0.01	0.0–2.5	0.68

↵2-150 Both models (1 and 2) are adjusted for age, sex, baseline OBS score, baseline depression, occupational class, education, and handicap.
Model 1includes smoking and alcohol before age of 65; model 2 includes smoking and alcohol after age of 65.
RR=risk ratio; significant p values are in bold.