Table 1

Characteristics of studies where patients with an established clinical diagnosis of idiopathic Parkinson's disease (IPD) or another parkinsonian condition were examined for response to apomorphine, acute levodopa, or chronic levodopa

First author/ ref No		Year of publication		Patients (n)		Assessment methods		Threshold for response		Number of tests for positive result	Follow up for chronic LD	Drug	Dose (mg)
First author/ ref No		Year of publication		IPD	Non-IPD	Assessment methods		Threshold for response		Number of tests for positive result	Follow up for chronic LD	Drug	Dose (mg)	Total
Oertel13	1989	23	19	42	Hoehn and Yahr	Unclear	Unclear	NA	APO	1/2/4/5/10
					Webster	Unclear
Hughes14	1990	65	35	100	Tapping	>15%	One of four		Acute LD	275
					12 m walk	>25%			APO	1.5/3.0/4.5
					Tremor	>2 points		Variable	Chronic LD	<1000
					Webster	>3 points
D'Costa15	1991	20	8	28	Tapping	>15%	One of two		APO	1/2/4/5/8/10
					6 m walk	>15%		1 month	Chronic LD	Variable
Schelosky16	1993	28	13	41	UPDRS III	>30%	One of three	NA	APO	2.0/3.5/5.0
					Tapping	>30%
					10 m walk	>15%
Bonuccelli17	1993	30	7	37	Tremor	>25%	Tremor & one other	NA	APO	0.7/3.5/7.0
					Tapping	>15%
					Rigidity	>25%
Linazasoro18	1993	25	18	43	Tapping	>15%	One of three	NA	APO	1.5/3/6/7.5
					20 m walk	>25%
					Tremor	>2 points
Roth19	1994	23	16	39	Columbia	>30%	Only one	NA	APO	0.05 mg/kg
Miranda20	1995	22	10	32	Tapping	>15%	One of three	NA	APO	1.5/3.0/5.0
					12 m walk	>25%
					Webster	>3 points
Zappia21	1997	70	4	74	UPDRS III	>20%	Only one		Acute LD	275
								6 months	Chronic LD	<1000

APO=apomorphine; LD=levodopa; NA=not available/applicable.