Main characteristics of patients according to dependency in one or more activities of daily living,21 and odds ratios (OR) with 95% confidence intervals (95% CIs) in separate age and sex adjusted logistic regression models (including demographics, comorbid conditions, medications, and objective tests) having disability as dependent variable. The variables were simultaneously entered into the separate regression models

	Independent (n=1122) n [%] or mean (SE)	Disabled (n=461) n [%] or mean (SE)	OR	95% CI
Demographics:
Age (y)	76.3 (0.3)^***	81.7 ( 0.4)	1.07	1.06–1.09^***
Sex (male)	564 [50.3]^***	183 [39.7]	0.83	0.66–1.05
Comorbid conditions:
Coronary disease	333 [29.7]^1-150	111 [24.1]	0.67	0.57–0.95^1-150
Hypertension	325 [29.0]^***	87 [18.9]	0.57	0.43–0.76^***
Diabetes	223 [19.9]	92 [20.0]	0.99	0.73–1.35
Renal disease	96 [8.6]^1-160	60 [13.0]	1.15	0.76–1.74
Chronic pulmonary disease	219 [19.5]	79 [17.1]	0.71	0.52–0.98^1-150
Atrial fibrillation	274 [24.4]	110 [23.9]	0.94	0.72–1.24
Comorbidity score index26	1.97 ( 0.04)^***	2.29 ( 0.08)	1.26	1.15–1.38^1-150
Medications:
Calcium antagonists	303 [27.0]^1-150	100 [21.7]	0.80	0.61–1.06
Digitalis	833 [74.2]	342 [74.2]	1.03	0.78–1.35
Diuretics	934 [83.2]	374 [81.1]	0.91	0.67–1.25
ACE inhibitors	455 [40.6]^***	123 [26.7]	0.57	0.44–0.72^***
Nitrates	583 [52.0]^1-150	213 [46.2]	0.86	0.68–1.08
Antiaggregants	134 [11.9]	40 [8.7]	0.71	0.48–1.04
Objective tests:
Cognitive dysfunction	150 [13.4]^***	265 [57.5]	6.51	3.80–11.15^***
Serum sodium (mEq/l)	139.8 (0.15)^1-160	138.8 (0.31)	0.95	0.90–1.01
Serum potassium (mEq/l)	4.3 (0.02)	4.3 (0.04)	0.66	0.43–1.01
Serum creatinine (mg/dl)	1.33 (0.03)^1-160	1.47 (0.05)	1.21	0.93–1.58
Systolic blood pressure (mm Hg)	137.0 (0.76)^***	130.0 (1.36)	0.98	0.97–0.99^1-160

↵1-150 p<0.05;
↵1-160 p<0.01;^***p<0.0001 (vdisabled in univariate analyses).