Nervous system
|
Memory and cognitive impairment, hyperactivity and behaviour disturbances, pseudodementia, cerebellar atrophy, peripheral neuropathy |
|
Ocular
|
Retinopathy |
|
Skin
|
Acne, hirsutism, alopecia, chloasma |
|
Liver
|
Enzyme induction |
|
Blood
|
Megaloblastic anaemia, thrombocytopenia, pseudolymphoma |
|
Immune system
|
IgA deficiency, drug induced systemic lupus erythematosus |
|
Endocrine system
|
Decreased thyroxine concentrations, increased cortisol and sex hormone metabolism |
|
Bone
|
Osteomalacia |
|
Connective tissue
|
Gingival hypertrophy, coarsened facial features, Dupuytren's contracture |