Table 1

Positive CSF 14-3-3 results and mean concentrations of CSF NSE, S-100b, and tau protein in patients with vCJD

Positive 14-3-3 (n) NSE (ng/ml) S-100b (ng/ml) tau (pg/ml)
Definite vCJD18 [36]26 (18) [33]1-150 1-151 0.99 (0.63) [36]1-150 1112 (1069) [35]1-150 1-151
Probable vCJD4 [9]41 (34) [4]1-151 1.02 (0.67) [9]806 (551) [8]1-151
Controls3 [34]14 (12) [29]1-151 0.44 (0.42) [34]345 (1124) [31]1-151

  • NSE, S-100b, and tau protein results are expressed as mean (SD). Total numbers of CSF samples analysed are shown in square brackets. Statistical analysis compared the CSF protein concentrations from patients with definite vCJD with those from control patients and was performed using a Mann-Whitney U test.

  • ↵1-150 p<0.001.

  • ↵1-151 Insufficient CSF to perform all analyses on all samples.