Mean (SD) MTR and D̄ histogram derived metrics of NAWM and NAGM from controls and patients with multiple sclerosis

CTRLs MS p Values1-150
No of subjects1830
NAWM:
 Mean MTR (%)41.2 (0.8)38.9 (1.3)0.001
 MTR peak location (%)35.2 (1.0)33.8 (1.8)0.004
 MTR peak height169.3 (20.7)147.5 (23.4)0.002
 Mean(mm2/s×10−3)0.820 (0.036)0.843 (0.038)0.04
Peak location0.745 (0.033)0.764 (0.032)NS
Peak height134.1 (15.3)119.3 (18.8)0.007
NAGM:
 Mean MTR (%)39.7 (0.5)39.2 (0.6)0.005
 MTR Peak location32.8 (1.0)31.4 (1.6)0.001
 MTR Peak height130.9 (11.9)132.7 (12.4)NS
 Mean(mm2/s×10−3)1.052 (0.050)1.086 (0.570)0.04
 D̄ Peak location0.848 (0.034)0.857 (0.035)NS
 D̄ Peak height68.2 (9.2)61.3 (8.5)0.01
  • 1-150 Student's t test for non-paired data.

  • MTR=Magnetisation transfer ratio; D̄=diffusivity.