Treatment strategies for restless legs syndrome (RLS)
| Drugs | Dose range | Specific issues | ||
| Dopaminergic (usually first choice): | ||||
| Levodopa DCI | 100–600 mg | Rebound/augmentation | ||
| Evening or divided dose | ||||
| Bromocriptine | 7.5 mg (divided dose) | Poor tolerance | ||
| Pergolide | 0.1–0.75 mg | Single or two evening doses | ||
| Ropinirole | 0.5–4 mg | daily/twice daily | ||
| DHEC | 10–40 mg | |||
| Pramipexole | 1.5 mg | Single evening dose | ||
| Cabergoline | 1–4 mg | Useful for augmentation | ||
| Apomorphine | 18–50 mg/12 h | Overnight sc infusion | ||
| Amantadine | 100–400 mg | |||
| Other drugs: | ||||
| Oxycodon | 2.5–25 mg | |||
| Propoxyphene | 100–260 mg | |||
| Clonazepam | 0.5–2 mg evening dose | Drowsiness | ||
| Triazolam | 0.125/0.25 mg | |||
| Nitrazepam | 2.5–10 mg | |||
| Carbamazepine | 100–600 mg | Single/divided doses | ||
| Gabapentin | 300–2400 mg | Quick dose escalation | ||
| Clonidine | 0.15–0.9 mg | |||
| Baclofen | 20–80 mg | Drowsiness/single dose | ||
| Only in iron deficient patients: | ||||
| Iron oxide | 100–200 mg/dose | Intravenous | ||
| Iron sulphate | 200 mg three times daily | Oral | ||