MR measurements of structural volume in healthy subjects: present study (KCL/UKC) and previous investigations
| Whole brain (litres) | LF (cm3) | RF (cm3) | LT (cm3) | RT (cm3) | Left hipp (mm3) | Right hipp (mm3) | Total hipp (mm3) | L P/hipp (mm3) | R P/hipp (mm3) | Total P/hipp (mm3) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actual: | ||||||||||||
| KCL/UKC | 1.14 (0.13) | 250.2 (39.1) | 249.0 (36.8) | 83.9 (11.0) | 91.2 (12.6) | 3642 (372) | 4130 (680) | 7772 (1008) | 3402 (548) | 3150 (497) | 6553 (960) | |
| Cook et al 27 | 3229 (397) | 3185 (393) | 6414 (786) | |||||||||
| Watson et al 25 | 4903 (684) | 5263 (652) | 10166 (NA) | |||||||||
| Breier et al 35 | 3800 (600) | 3700 (400) | 7500 (NA) | |||||||||
| Murphy et al 36 | 1.19 (0.16) | |||||||||||
| Murphyet al 37 | 1.07 (0.13) | 64.4 (7.8) | 68.6 (8.5) | |||||||||
| Bhatia et al 38 | 1.31 (0.09) | 79.9 (7.9) | 82.3 (8.0) | 3780 (551) | 3770 (610) | 7550 (NA) | ||||||
| Aylward et al 39 | 1.32 (0.18) | |||||||||||
| Schlaepferet al 40 | 1.34 (0.13) | |||||||||||
| Lehericyet al 41 | 2880 (90) | 3010 (80) | 5890 (NA) | |||||||||
| Howard et al 42 | 1.00 (NA) | |||||||||||
| Bremneret al 13 | 54.8 (9.0) | 63.6 (10.9) | 1233 (163) | 1286 (175) | 2519 (NA) | |||||||
| Bigler et al 43 | 1.34 (0.04) | 2500 (290) | 2550 (270) | 5050 (NA) | ||||||||
| Pantelet al 44 | 0.86 (0.05) | 53.3 (0.7) | 52.2 (4.8) | 47.6 (7.2) | 48.4 (7.2) | |||||||
| Woodruff et al 45 | 1.15 (0.06) | 78.6 (10.3) | NA | 1860 (370) | NA | NA | ||||||
| Mackayet al 5 | 1.15 (NA) | 78.9 (6.0) | 81.4 (7.4) | 2620 (350) | 2720 (410) | 5340 (NA) | 3240 (530) | 3230 (500) | 6470 (NA) | |||
| Briellmann et al 47 | 4186 (459) | 4212 (532) | 8398 (NA) | |||||||||
| Cheon et al 48 | 2198 (NA) | 2233 (NA) | 4420 (NA) | |||||||||
| Hashimoto et al 49 | 1.10 (0.14) | NA | NA | 6308 (850) | ||||||||
| Laakso et al 50 | 3189 (536) | 3394 (519) | 6583 (NA) | |||||||||
| Deicken et al 51 | 3760 (528) | 4018 (519) | 7778 (NA) | |||||||||
| Dickey et al 52 | 3780 (760) | 3890 (590) | 7670 (NA) | 3280 (690) | 2910 (520) | 6190 (NA) | ||||||
| Bernasconi et al 29 | 2287 (282) | 2510 (285) | 4797 (NA) | |||||||||
| Warwick et al 53 | M | 1.44 (0.09) | 77.8 (11.0) | 83.9 (11.3) | 85.2 (6.7) | 91.2 (5.4) | ||||||
| F | 1.25 (0.07) | 70.0 (9.8) | 74.9 (7.9) | 73.5 (6.6) | 77.1 (5.2) | |||||||
| Maguire et al 59 | 4092 (324) | 4255 (424) | 8347 (NA) | |||||||||
| “Normalised”: | ||||||||||||
| KCL/UKC | 1.14 (0.06) | 250.2 (23.6) | 249.0 (21.4) | 83.9 (7.3) | 91.2 (12.3) | 3641 (372) | 4130 (680) | 7772 (1008) | 3402 (548) | 3750 (450) | 6553 (940) | |
| Jack et al 24 | 2500 (100) | 2800 (100) | 5300 (NA) | |||||||||
| Yoneda et al 4 | 2470 (320) | 2540 (230) | 5010 (520) | 4740 (620) | 4700 (570) | 9440 (1130) | ||||||
| Fox et al 34 | 3021 (280) | 3038 (267) | 6059 (NA) | |||||||||
| Laakso et al 54 * | 3206 (548) | 3450 (498) | 6656 (NA) | |||||||||
| Mori et al 12 | 3100 (NA) | 3304 (NA) | 6404 (NA) | 2237 (551) | 1946 (513) | 4183 (NA) | ||||||
| (cortex only) | (cortex only) | (cortex only) | ||||||||||
| Köhler et al.18 | NA | NA | 2614 (NA) | NA | NA | 5210 (NA) | ||||||
| Briellmannet al.47 | NA | NA | 8398 (NA) | |||||||||
| Ho et al 28 | 3630 (210) | 3960 (270) | 7590 (NA) | |||||||||
| Kuznieckyet al 55 | 3571 (311) | 3696 (310) | 7267 (620) | |||||||||
| Van Paesschenet al 26 | NA | NA | 10360 (832) | |||||||||
| Woermann et al 56 | 3200 (214) | 3184 (245) | 6384 (NA) | |||||||||
| Deicken et al 51 * | 3770 (455) | 4023 (375) | 7793 (NA) | |||||||||
| Golebiewskiet al 57 | 2641 (276) | 2657 (270) | 5298 (NA) | |||||||||
| Kuznieckyet al 58 | 3575 (292) | 3692 (293) | 7267 (NA) | |||||||||
| Maguire et al 59 | 3918 (224) | 4080 (325) | 7998 (NA) | |||||||||
| Intracranial volume (%): | ||||||||||||
| KCL/UKC | 86.2 (4.4) | 18.8 (1.9) | 18.8 (1.7) | 6.3 (0.5) | 6.9 (0.9) | 0.28 (0.04) | 0.31 (0.06) | 0.59 (0.09) | 0.26 (0.05) | 0.24 (0.03) | 0.50 (0.07) | |
| Murphyet al 46 | 74.1 (1.9) | 18.5 (0.9) | 18.4 (0.9) | 4.9 (0.5) | 4.7 (0.5) | 0.22 (0.03) | 0.22 (0.03) | 0.44 (0.07) | 0.21 (0.03) | 0.22 (0.04) | 0.42 (0.05) | |
| Murphy et al 37 | 76.8 (3.2) | 4.6 (0.6) | 4.9 (0.6) | |||||||||
| Killiany et al 14 | 4.1 (0.3) | 4.2 (0.5) | 0.18 (0.01) | 0.19 (0.02) | 0.37 (NA) | |||||||
| Pantelet al 44 | 73.7 (4.0) | 4.4 (0.1) | 4.3 (0.4) | 4.0 (0.6) | 4.0 (0.6) | |||||||
| Dickey et al 52 | 0.24 (0.06) | 0.25 (0.04) | 0.49 (NA) | 0.21 (0.19) | 0.19 (0.03) | 0.40 (NA) | ||||||
Data presented as in the original published studies—actual or normalised volumes or % intracranial volume. Normalised volumes by formula of Jack et al 24 except *where own formula used. NA=not available.