SF-36 and EQ-5D measures over time and effect sizes of BoNT/A treatment within the HRQL dimensions assessed in 50 patients with focal dystonia
| Cranial dystonia | Cervical dystonia | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | First follow up | Second follow up | BoNT/A effect size | Baseline | First follow up | Second follow up | BoNT/A effect size | ||
| SF-36: | |||||||||
| PF | 63.6 (26.0) | 70.8 (27.9)4-150 | 59.6 (29.6) | 0.3 (0.6) | 73.8 (22.7) | 74.6 (27.5) | 74.2 (23.1) | 0.03 (0.9) | |
| SF | 67.9 (27.5) | 77.4 (25.3)4-160 | 68.4 (29.1) | 0.4 (0.7) | 74.4 (20.6) | 83.0 (19.6)4-160 | 70.9 (24.1) | 0.4 (0.6) | |
| RP | 53.0 (34.1) | 63.0 (37.6)4-150 | 49.0 (37.8) | 0.3 (0.6) | 52.0 (31.4) | 64.0 (35.4)4-150 | 46.0 (29.5) | 0.4 (0.7) | |
| RE | 61.2 (41.6) | 75.8 (34.1)4-150 | 59.8 (40.8) | 0.4 (0.8) | 75.9 (39.2) | 78.5 (33.3) | 73.2 (37.3) | 0.1 (0.4) | |
| MH | 62.2 (16.9) | 70.9 (21.0)4-160 | 66.4 (18.9) | 0.5 (0.7) | 62.7 (19.0) | 74.6 (14.4)4-160 | 59.0 (21.6) | 0.7 (1.0) | |
| VIT | 54.8 (22.0) | 63.2 (24.6)4-150 | 53.6 (24.3) | 0.4 (0.7) | 55.6 (22.4) | 64.8 (23.0)4-160 | 55.0 (23.8) | 0.4 (0.7) | |
| BP | 60.5 (24.3) | 64.2 (27.8) | 60.8 (27.6) | 0.2 (0.6)4-151 | 55.7 (25.0) | 74.2 (20.5)4-160 | 57.5 (26.5) | 0.8 (0.9)4-151 | |
| GH | 47.8 (18.1) | 51.3 (19.6) | 48.3 (19.8) | 0.2 (0.7) | 53.2 (19.6) | 52.3 (18.1) | 49.0 (18.5) | −0.1 (0.7) | |
| EQ-5D: | |||||||||
| UI | 0.59 (0.26) | 0.66 (0.29) | 0.63 (0.27) | 0.3 (0.9) | 0.60 (0.24) | 0.76 (0.21)4-160 | 0.66 (0.21) | 0.6 (0.9) | |
| VAS | 59.6 (19.9) | 67.4 (21.4)4-150 | 62.2 (20.3) | 0.4 (0.9) | 57.0 (21.2) | 69.2 (18.0)4-150 | 58.8 (15.9) | 0.6 (1.1) | |
↵4-150 p<0.05;
↵4-160 p<0.01 for difference of first follow up assessment compared with baseline (paired ttest); no significant differences between second follow up and baseline assessments;
↵4-151 p<0.01 for difference in BoNT/A effect size between cranial and cervical dystonia (unpaired ttest); BoNT/A effect size=(first follow up score–baseline score)/1 SD of baseline scores; PF=physical functioning; SF=social functioning; RP=role-physical; RE=role-emotional; MH=mental health; VIT=vitality; BP=bodily pain; GH=general health; UI=utility index; VAS=visual analogue scale.