Feature | I-1 | II-1 | II-2 |
---|---|---|---|
*Data from the initial evaluation. | |||
NA, not available. | |||
Age of onset (y) | 51 | 46 | 49 |
Age of death (y) | 66 | 52 | – |
Duration (y) | 15 | 6 | – |
Behavioural abnormalities | Anxiety, apathy, paranoid thinking | Paranoid, obsessive behaviour, social shyness | Aberrant behaviour, anxiety, dysphoria |
Neuropsychological domains affected* | Memory, visuospatial tasks, executive function | Memory, attention, executive function | Visuospatial tasks attention, memory |
Neuropathology | NA | Stage VI Braak and Braak | – |
PSEN1 mutation | NA | + | + |
APOE genotype | NA | ε3ε3 | ε2ε3 |