Protein/peptide | Disorder | Aggregate | Neuronal location |
---|---|---|---|
APP, amyloid precursor protein; Aβ, β-amyloid peptide; FTDP-17, frontotemporal dementia with parkinsonism linked to chromosome 17; CBD, corticobasal degeneration; PSP, progressive supranuclear palsy; DLB, Dementia with Lewy bodies. | |||
APP/Aβ | Alzheimer's disease | Amyloid | Extracellular |
Tau | Alzheimer's disease, FTDP-17, Pick's disease, CBD, PSP | Paired helical and straight filaments | Cytoplasmic |
α-Synuclein | Parkinson's disease, DLB | Lewy body | Cytoplasmic |
Multisystem atrophy | Inclusion body | Glial cells | |
Huntingtin | Huntington's disease | Inclusion body | Cytoplasmic and intranuclear |
Prion protein | Prion disorders | Amyloid | Extracellular |