Autoantibodies and their connective tissue disease associations
| Immunofluorescence pattern | Antibody | Disease associations |
| Rim ANA | Anti-native DNA (anti-dsDNA) | SLE (50%) |
| Homogeneous ANA | Anti-histone | Drug-induced lupus (97%) NB low titre (< 1:320) in normals |
| Speckled ANA | Anti-Ro (SS-A) | Sjögren's (75%), SLE (30%) |
| Anti-La (SS-B) | Sjögren's (60%), SLE (15%) | |
| Anti-Scl-70 | Systemic sclerosis (50%) | |
| Anti-Sm | SLE (75%) | |
| Anti-RNP (anti-U1-nRNP) | MCTD (95%), SLE (30%) | |
| Nucleolar ANA | Anti-PM-Scl | ? Identifies polymyositis/ scleroderma overlap |
| Other organelles | Anti-centromere | Systemic sclerosis (85%) |