Volumes of brain regions by group
| Brain region | Schizophrenic siblings mean (SD) | Obligates mean (SD) | Non-affected, non-carrier siblings mean (SD) | Significant between group differences by repeated measures ANOVA (df=2,3) |
|---|---|---|---|---|
| Volumes expressed in cm3. | ||||
| Whole | ||||
| Brain | 1193.2 (50.2) | 1259.2 (85.6) | 1262.6 (68.0) | SCH<OBL, NANC |
| (F=7.8, p=0.01) | ||||
| Cortical | ||||
| Structures | 273.8 (9.5) | 293.7 (16.0) | 293.4 (13.4) | SCH<OBL, NANC |
| Prefrontal lobe left | 63.9 (6.3) | 67.8 (6.1) | 66.2 (3.4) | (F=4.7, p=0.04) |
| Prefrontal lobe right | 65.9 (3.0) | 71.1 (6.4) | 73.5 (7.5) | |
| Temporal lobe left | 70.9 (3.4) | 75.6 (6.9) | 74.2 (7.8) | |
| Temporal lobe right | 73.0 (2.4) | 79.3 (8.4) | 79.5 (6.9) | |
| Subcortical | ||||
| Structures | 28.1 (2.4) | 27.6 (3.0) | 28.8 (2.7) | No significant |
| Thalamus left | 5.2 (0.3) | 5.3 (0.5) | 5.7 (0.5) | between group |
| Thalamus right | 5.2 (0.5) | 5.4 (0.6) | 5.7 (0.6) | differences |
| Caudate left | 4.0 (0.5) | 3.9 (0.5) | 3.8 (0.4) | (F=3.2, p=0.095) |
| Caudate right | 3.9 (0.5) | 3.7 (0.7) | 3.8 (0.3) | |
| Lentiform nucleus left | 4.9 (0.8) | 4.6 (0.7) | 4.8 (0.8) | |
| Lentiform nucleus right | 4.8 (0.6) | 4.6 (0.8) | 4.9 (0.7) | |
| Amygdalohippocampal | ||||
| complexes | 7.8 (0.8) | 8.4 (0.5) | 8.8 (0.3) | SCH, OBL<NANC |
| Left | 3.6 (0.5) | 3.9 (0.4) | 4.1 (0.3) | (F=16.5, p=0.001) |
| Right | 4.1 (0.4) | 4.5 (0.2) | 4.7 (0.3) | |
| Intracerebral | ||||
| Ventricular system | 16.6 (6.4) | 9.6 (5.2) | 18.9 (11.4) | OBL<SCH |
| Lateral ventricle left | 7.0 (2.9) | 5.0 (2.9) | 10.3 (7.6) | (F=5.4, p=0.03) |
| Lateral ventricle right | 7.9 (4.4) | 3.3 (1.8) | 7.0 (2.9) | |
| 3rd Ventricle | 0.9 (0.3) | 0.6 (0.2) | 0.9 (1.0) | |
| 4th Ventricle | 0.7 (0.3) | 0.8 (0.5) | 0.6 (0.1) | |