Clinical features
| Patient | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
| Sex | M | M | M | M | M | M | M | M | M | V |
| Age of onset (y) | 54 | 45 | 44 | 39 | 31 | 23 | 55 | 30 | 57 | 53 |
| Family history | - | - | - | - | - | - | - | - | - | - |
| Duration in years | 6 | 8 | 18 | 7 | 35 | 10 | 6 | 11 | 8 | 18 |
| First diagnosis | ALS | CM | LS | MS | ALS | LS | Park | MS | ALS | LS |
| Diagnostic delay (y) | 5 | 2 | 0 | 6 | 28 | 0 | 2 | 10 | 3 | 0 |
| Weakness | - | - | - | - | + | - | + | - | - | - |
| Site of onset | L leg | L leg | Legs | Legs | R arm | Legs | R leg | Legs | Speech | L leg |
| Spasticity/Ashworth | 3 | 2 | 3 | 2 | 2 | 2 | NT | 2 | 2 | 2 |
| LMN signs | - | - | - | - | - | - | - | - | - | + |
| Sensory deficit | - | - | - | - | - | - | - | - | - | - |
| Pseudobulbar affect | + | + | - | - | - | - | + | - | + | + |
| Urinary incontinence | + | + | - | - | - | - | - | - | - | + |
| Barthel/Rankin scale | 16/3 | 16/3 | 18/2 | 20/2 | 4/5 | 20/2 | 11/4 | 18/2 | 17/3 | 17/3 |
| Medical aids | WCH | WCH | W | - | WCH | - | WCH | W | W | WCH |
+=Present; -=absent/negative; NT=not tested; ALS=amyotrophic lateral sclerosis; CM=cervical myelopathy; MS=multiple sclerosis; LS=lateral sclerosis; Park=Parkinson; Ashworth scale 0–4; LMN=lower motor neuron; WCH=wheel chair; W=walker.