Heart rate variability (five minute resting study and deep breathing test) in healthy controls and in patients with Huntington's disease
| Controls (n=60) | Patients (total) (n=18) | E-HD group (n=9) | M-HD group (n=9) | |
|---|---|---|---|---|
| All HRV indices (except the LF/HF ratio) were log transformed. The values given are means (SD). | ||||
| E-HD, Early stage Huntington's disease; M-HD, middle stage Huntington's disease. HRV, heart rate variability; HRr, resting heart rate; CVr, CVd, coefficient of variation; RMSSDr, RMSSDd, root mean square of successive differences; MCR, mean circular resultant; LF, low frequency; HF, high frequency. | ||||
| Statistical comparison was by one way analysis of variance with post hoc comparison of means by Duncan's multiple range test: *p<0.05 compared with healthy controls; †p<0.05 compared with the E-HD group. | ||||
| 5 min resting study | ||||
| HRr (beats/min) | 73.1 (11.1) | 78.7 (12.0) | 78.2 (10.5) | 79.2 (13.9) |
| CVr (%) | 0.65 (0.19) | 0.58 (0.21) | 0.69 (0.15) | 0.46 (0.20)*† |
| RMSSDr (ms) | 1.43 (0.28) | 1.32 (0.35) | 1.44 (0.30) | 1.20 (0.38)* |
| LF power (ms2) | 2.87 (0.45) | 2.88 (0.41) | 3.08 (0.32) | 2.68 (0.39) |
| HF power (ms2) | 2.66 (0.46) | 2.53 (0.64) | 2.84 (0.35) | 2.20 (0.71)*† |
| LF/HF ratio | 2.33 (2.19) | 3.15 (2.45) | 2.07 (1.09) | 4.23 (2.97)* |
| Deep breathing test | ||||
| CVd (%) | 0.88 (0.19) | 0.83 (0.19) | 0.92 (0.09) | 0.74 (0.22)* |
| RMSSDd (ms) | 1.58 (0.24) | 1.51 (0.25) | 1.60 (0.15) | 1.42 (0.30) |
| MCR | −1.38 (0.25) | −1.51 (0.28) | −1.42 (0.22) | −1.60 (0.32)* |