Baseline and follow up data for parahippocampal volume, hippocampal gyrus volume, and MTA score
| Hippocampus volume at baseline* | ||||
|---|---|---|---|---|
| Highest tertile | Middle tertile | Lowest tertile | p Value trend analysis | |
| (A) Baseline and follow up data according to hippocampal volume at baseline: | ||||
| Number | 9 | 9 | 12 | |
| Baseline data | ||||
| Age (y) | 60.6 (8.6) | 65.9 (8.4) | 66.9 (10.9) | 0.15 |
| MMSE score | 27.8 (1.7) | 27.9 (1.7) | 27.3 (2.1) | 0.50 |
| Delayed recall (z score) | −1.15 (0.84) | −0.42 (0.84)† | −1.1 (0.80)† | 0.94 |
| Follow up data | ||||
| Change MMSE | 0.0 (2.2)§ | −0.78 (1.7) | −4.7 (4.4)§ | 0.002 |
| Change delayed recall | 0.73 (1.2)§ | −0.33 (1.2)† | −0.29 (1.5)¶ | 0.18 |
| AD/no AD at follow up (% AD) | 0/9 (0) | 1/8 (13) | 6/5 (55)† | 0.003 |
| CD/no CD at follow up (% CD) | 0/6 (0)§ | 2/7 (30) | 8/3 (72)† | 0.001 |
| Parahippocampal gyrus volume at baseline* | ||||
|---|---|---|---|---|
| Highest tertile | Middle tertile | Lowest tertile | p Value trend analysis | |
| (B) Baseline and follow up data according to parahippocampal gyrus volume at baseline: | ||||
| Number | 12 | 10 | 8 | |
| Baseline data | ||||
| Age (y) | 64.2 (10.4) | 64.2 (9.3) | 66.1 (10.0) | 0.69 |
| MMSE score | 27.0 (2.0) | 28.2 (1.9) | 27.8 (1.7) | 0.31 |
| Delayed recall (z score) | −0.93 (0.92)‡ | −0.80 (0.93) | −1.05 (0.76) | 0.80 |
| Follow up data | ||||
| Change MMSE | −0.86 (2.3)** | −1.1 (3.1) | −4.6 (4.5)† | 0.05 |
| Change delayed recall | 0.61 (1.3)** | −0.11 (1.2)† | −0.64 (1.4)‡ | 0.09 |
| AD/no AD at follow up (% AD) | 2/10 (17) | 2/8 (20) | 3/4 (43)† | 0.24 |
| CD/no CD at follow up (% CD) | 2/7 (22)§ | 3/7 (30) | 5/2 (71)† | 0.05 |
| MTA score at baseline* | ||||
|---|---|---|---|---|
| Highest tertile | Middle tertile | Lowest tertile | p Value trend analysis | |
| Values are means (SD). *Tertiles are based on a reference population of healthy subjects. A low tertile score indicates a small hippocampal or parahippocampal gyrus volume, or an high MTA score; †one patient with missing data; ‡two patients with missing data; §three patients with missing data; ¶four patients with missing data; **five patients with missing data. | ||||
| MMSE, Mini mental state examination; AD, Alzheimer type dementia; CD, cognitive decline: patients with Alzheimer type dementia at follow up or patients with severe cognitive decline at follow up without dementia. | ||||
| (C) Baseline and follow up data according to MTA score at baseline: | ||||
| Number | 12 | 6 | 13 | |
| Baseline data | ||||
| Age (y) | 59.2 (8.1) | 67.9 (2.0) | 68.8 (10.1) | 0.01 |
| MMSE score | 28.3 (1.4) | 27.8 (1.9) | 27.0 (2.0) | 0.08 |
| Delayed recall (z score) | −0.86 (0.72)† | −0.58 (1.1) | −1.1 (0.80)† | 0.46 |
| Follow up data | ||||
| Change MMSE score | −0.73 (2.1)† | −1.2 (1.6)† | −3.9 (5.0)¶ | 0.05 |
| Change delayed recall score | 0.11 (1.4)§ | 0.14 (1.4)† | −0.16 (1.3)¶ | 0.67 |
| AD/no AD at follow up (% AD) | 1/11 (8) | 0/6 (0) | 6/6 (50)† | 0.01 |
| CD/no CD at follow up (% CD) | 2/9 (18)† | 0/5 (0)† | 8/3 (73)‡ | 0.01 |