Summary of “modern” dopamine agonist monotherapy trials
| Agonist | |||||
|---|---|---|---|---|---|
| Ropinirole | Pramipexole | Cabergoline | Pergolide | ||
| ?, Unpublished; *p<0.05 or less; NA, not available. | |||||
| Date published | 1999 | 2000 | ? | ? | |
| Patient numbers | 268 | 301 | 419 | 294 | |
| Duration of trial (years) | 5 | 2 | 5 | 3 | |
| Rescue levodopa allowed | Yes | Yes | Yes | No | |
| Dykinesia incidence | Agonist | 20%* | 10%* | 22%* | 16%* |
| v | v | ||||
| Levodopa | 46% | 31% | |||
| Fluctuations incidence | Agonist | NA | 24% | ||
| Levodopa | NA | 38% | 34% | 33% | |